Tumour necrosis factor alpha contributes to protection against Giardia lamblia infection in mice.

Tumour necrosis factor alpha contributes to protection against Giardia lamblia infection in mice. Research Abstract Details 

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Tumour necrosis factor alpha contributes to protection against Giardia lamblia infection in mice. Abstract Text:

P Zhou,E Li,T Shea-Donohue,S M Singer,

Giardia lamblia is a ubiquitous parasite that causes diarrhoea. Effective control of Giardia infections in mice has been shown to involve IgA, T cells, mast cells and IL-6. We now show that Tumour necrosis factor alpha (TNFalpha) also plays an important role in the early control of giardiasis. Mice treated with neutralizing anti-TNFalpha antibodies or genetically deficient in TNFalpha were infected with the G. lamblia clone GS/(M)-H7. In both cases, mice lacking TNFalpha had much higher parasite numbers than controls during the first 2 weeks of infections. However, anti-parasite IgA levels, mast cell responses, and IL-4 and IL-6 mRNA levels do not appear significantly altered in the absence of TNFalpha. In addition, we show that mice infected with G. lamblia exhibit increased intestinal permeability, similar to human Giardia infection, and that this increase occurs in both wild-type and TNFalpha deficient mice. We conclude that TNFalpha is essential for host resistance to G. lamblia infection, and that it does not exert its effects through mechanisms previously implicated in control of this parasite.

Tumour necrosis factor alpha contributes to protection against Giardia lamblia infection in mice. Publishing Authors By Initials

P Zhou,E Li,T Shea-Donohue,SM Singer,

For similar peptides: intercellular signaling peptides and proteins: cytokines: monokines: tumor necrosis factor-alpha research abstracts see: peptides: intercellular signaling peptides and proteins: cytokines: monokines: tumor necrosis factor-alpha research

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Tumour necrosis factor alpha contributes to protection against Giardia lamblia infection in mice. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Parasite immunology

VOLUME: 29

Page Numbers: 367-74

Journal Abbreviation: Parasite Immunol.

ISSN: 0141-9838

DAY: 3

MONTH: Jul

YEAR: 2007

Tumour necrosis factor alpha contributes to protection against Giardia lamblia infection in mice. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7910948

Tumour necrosis factor alpha contributes to protection against Giardia lamblia infection in mice. Keywords Mesh Terms:

KEYWORDS: Tumor Necrosis Factor-alpha

MESH TERMS: metabolism

Chemical & Substance for Abstract: Tumour necrosis factor alpha contributes to protection against Giardia lamblia infection in mice. Information

Substance Name: Tumor Necrosis Factor-alpha

Registry Number: 0

Grant and Affiliation Information for Tumour necrosis factor alpha contributes to protection against Giardia lamblia infection in mice.

AFFILIATION: Department of Biology, Georgetown University, Washington, DC 20057, USA.

Country: England

AGENCY: United States NIAID

GRANT: AI/DK-049316

ACRONYM: AI

MEDLINETA: Parasite Immunol

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