Tumour invasion and metastasis initiated by microRNA-10b in breast cancer.

Tumour invasion and metastasis initiated by microRNA-10b in breast cancer. Research Abstract Details 

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Tumour invasion and metastasis initiated by microRNA-10b in breast cancer. Abstract Text:

Patricia S Steeg,Patricia S Steeg,

MicroRNAs have been implicated in regulating diverse cellular pathways. Although there is emerging evidence that some microRNAs can function as oncogenes or tumour suppressors, the role of microRNAs in mediating cancer metastasis remains unexplored. Here we show, using a combination of mouse and human cells, that microRNA-10b (miR-10b) is highly expressed in metastatic breast cancer cells and positively regulates cell migration and invasion. Overexpression of miR-10b in otherwise non-metastatic breast tumours initiates robust invasion and metastasis. Expression of miR-10b is induced by the transcription factor Twist, which binds directly to the putative promoter of mir-10b (MIRN10B). The miR-10b induced by Twist proceeds to inhibit translation of the messenger RNA encoding homeobox D10, resulting in increased expression of a well-characterized pro-metastatic gene, RHOC. Significantly, the level of miR-10b expression in primary breast carcinomas correlates with clinical progression. These findings suggest the workings of an undescribed regulatory pathway, in which a pleiotropic transcription factor induces expression of a specific microRNA, which suppresses its direct target and in turn activates another pro-metastatic gene, leading to tumour cell invasion and metastasis.

Tumour invasion and metastasis initiated by microRNA-10b in breast cancer. Publishing Authors By Initials

PS Steeg,PS Steeg,

For similar enzymes and coenzymes: enzymes: hydrolases: acid anhydride hydrolases: gtp phosphohydrolases: gtp-binding proteins: monomeric gtp-binding proteins: rho gtp-binding proteins research abstracts see: enzymes and coenzymes: enzymes: hydrolases: acid anhydride hydrolases: gtp phosphohydrolases: gtp-binding proteins: monomeric gtp-binding proteins: rho gtp-binding proteins research

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Tumour invasion and metastasis initiated by microRNA-10b in breast cancer. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Nature

VOLUME: 449

Page Numbers: 682-8

Journal Abbreviation: Nature

ISSN: 1476-4687

DAY: 26

MONTH: 09

YEAR: 2007

Tumour invasion and metastasis initiated by microRNA-10b in breast cancer. Information

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LANGUAGE: eng

NlmUniqueID: 410462

Tumour invasion and metastasis initiated by microRNA-10b in breast cancer. Keywords Mesh Terms:

KEYWORDS: rho GTP-Binding Proteins

MESH TERMS: metabolism

Chemical & Substance for Abstract: Tumour invasion and metastasis initiated by microRNA-10b in breast cancer. Information

Substance Name: rho GTP-Binding Proteins

Registry Number: EC 3.6.5.2

Grant and Affiliation Information for Tumour invasion and metastasis initiated by microRNA-10b in breast cancer.

AFFILIATION: Whitehead Institute for Biomedical Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA.

Country: England

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MEDLINETA: Nature

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