Tumor-suppressive effect of retinoid receptor-induced gene-1 (RRIG1) in esophageal cancer.

Tumor-suppressive effect of retinoid receptor-induced gene-1 (RRIG1) in esophageal cancer. Research Abstract Details 

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Tumor-suppressive effect of retinoid receptor-induced gene-1 (RRIG1) in esophageal cancer. Abstract Text:

Jie Huang,Zheng D Liang,Tsung-Teh Wu,Ashraful Hoque,Hongli Chen,Yan Jiang,Hongfu Zhang,Xiao-Chun Xu,

We previously showed that induction of retinoid receptor-induced gene-1 (RRIG1) expression inhibited RhoA activation and tumor cell colony formation, invasion, and proliferation, and these effects are associated with the suppression of extracellular signal-regulated protein kinases 1 and 2 phosphorylation and cyclooxygenase-2 expression. To further elucidate its role in tumor cell growth, gene expression, and tumorigenesis, we determined RRIG1 expression in breast and esophageal tissue specimens and then stably transfected RRIG1 into a TE-8 esophageal squamous cell carcinoma (SCC) cell line. We found that RRIG1 was expressed in normal mammary glands (10 of 10) but not all ductal carcinoma in situ [11 of 19 (57.9%), P = 0.018] and invasive cancer [14 of 30 (46.7%), P = 0.0023] tissues. Similarly, RRIG1 was expressed in normal esophageal epithelium (22 of 22) but not all dysplastic [6 of 43 (14%), P = 0.0001] and SCC [50 of 122 (41%), P = 0.0001] tissues. Furthermore, RRIG1 expression correlated positively with tumor differentiation but inversely with lymph node metastasis of esophageal SCC. Finally, the stable transfection of RRIG1 inhibited esophageal SCC cell growth and the expression of extracellular signal-regulated protein kinases 1 and 2 and cell cycle-related genes (e.g., cyclin D1, phosphorylated Rb, and E2F). RRIG1-transfected sublines also inhibited tumor development in nude mice. The results of this study indicate that RRIG1 plays a role in suppressing tumorigenesis.

Tumor-suppressive effect of retinoid receptor-induced gene-1 (RRIG1) in esophageal cancer. Publishing Authors By Initials

J Huang,ZD Liang,TT Wu,A Hoque,H Chen,Y Jiang,H Zhang,XC Xu,

For similar proteins: neoplasm proteins: tumor suppressor proteins research abstracts see: proteins: neoplasm proteins: tumor suppressor proteins research

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Tumor-suppressive effect of retinoid receptor-induced gene-1 (RRIG1) in esophageal cancer. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Cancer research

VOLUME: 67

Page Numbers: 1589-93

Journal Abbreviation: Cancer Res.

ISSN: 0008-5472

DAY: 15

MONTH: Feb

YEAR: 2007

Tumor-suppressive effect of retinoid receptor-induced gene-1 (RRIG1) in esophageal cancer. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 2984705

Tumor-suppressive effect of retinoid receptor-induced gene-1 (RRIG1) in esophageal cancer. Keywords Mesh Terms:

KEYWORDS: Tumor Suppressor Proteins

MESH TERMS: genetics

Chemical & Substance for Abstract: Tumor-suppressive effect of retinoid receptor-induced gene-1 (RRIG1) in esophageal cancer. Information

Substance Name: Tumor Suppressor Proteins

Registry Number: 0

Grant and Affiliation Information for Tumor-suppressive effect of retinoid receptor-induced gene-1 (RRIG1) in esophageal cancer.

AFFILIATION: Department of Clinical Cancer Prevention, University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA.

Country: United States

AGENCY: United States NCI

GRANT: R21 CA 10226

ACRONYM: CA

MEDLINETA: Cancer Res

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