Tumor-specific tRNA modifications in mouse plasmacytomas and other tumors.

Tumor-specific tRNA modifications in mouse plasmacytomas and other tumors. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Tumor-specific tRNA modifications in mouse plasmacytomas and other tumors. Abstract Text:

J F Mushinski,M Marini,

RPC-5 chromatography has been used to analyze the aa-tRNA populations found in normal organs and in various tumors in experimental animals. The most extensively studied animal systems have been mineral-oil-induced mouse plasmacytomas and carcinogen-induced rat hepatomas. Certain aa-tRNA species appear to be tumor-specific, e.g., rat hepatoma phenylalanyl-tRNA1 and plasmacytoma asparaginyl-tRNAs2-4. In addition, one of the tumor-specific peaks of asparaginyl-tRNA can be found in normal livers of animals bearing plasmacytomas at a distant site. Many other significant quantitative and qualitative differences among histologically similar plasmacytomas and between normal tissues and plasmacytomas were observed in the chromatographic patterns of isoaccepting aa-tRNAs for 11 of 20 amino acids. Some of the qualitative differences in chromatographic patterns could be correlated with the tumorous nature of the tissue using computer analysis. The program utilized cluster analysis to compare the RPC-5 patterns of aa-tRNAs from 11 plasmacytomas and two normal tissues for each of the 20 amino acids. The variations in these chromatographic profiles are though to be caused by varying degrees of incomplete synthesis of some of the normally modified nucleosides in tRNAs.

Tumor-specific tRNA modifications in mouse plasmacytomas and other tumors. Publishing Authors By Initials

JF Mushinski,M Marini,

For similar genetic phenomena: variation (genetics) research abstracts see: genetic phenomena: variation (genetics) research

PUBMED ID PMID:

MEDLINE DATE:

Tumor-specific tRNA modifications in mouse plasmacytomas and other tumors. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Recent results in cancer research. Fortschritte de

VOLUME: 84

Page Numbers: 121-32

Journal Abbreviation: Recent Results Cancer Res.

ISSN: 0080-0015

DAY: 13

MONTH: 02

YEAR: 1983

Tumor-specific tRNA modifications in mouse plasmacytomas and other tumors. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 44671

Tumor-specific tRNA modifications in mouse plasmacytomas and other tumors. Keywords Mesh Terms:

KEYWORDS: Variation (Genetics)

MESH TERMS: genetics

Chemical & Substance for Abstract: Tumor-specific tRNA modifications in mouse plasmacytomas and other tumors. Information

Substance Name: RNA, Transfer

Registry Number: 9014-25-9

Grant and Affiliation Information for Tumor-specific tRNA modifications in mouse plasmacytomas and other tumors.

AFFILIATION:

Country: GERMANY, WEST

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Recent Results Cancer Res

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Tumor-specific tRNA modifications in mouse plasmacytomas and other tumors Related Publications

• Allergic manifestations in very low-birthweight infants: a 6-year follow-up.
• Brain-derived neurotrophic factor in neuronal survival and behavior-related plasticity.
• Control of graft-versus-host disease with maintenance of the graft-versus-leukemia effect in a murine allogeneic transplant model using retrovirally transduced murine suicidal lymphocytes.
• Deficiency of cartilage-associated protein in recessive lethal osteogenesis imperfecta.
• Do airway secretions play an underappreciated role in acute respiratory distress syndrome?
• Hydrolysed proteins in preterm formula: influence on plasma aminoacids, blood fatty acids and insulinaemia.
• Inflammation and tumor microenvironments: defining the migratory itinerary of mesenchymal stem cells.
• Intracellular study of presumed interneurons in the ventrobasal complex of cats with chronic cortical ablations.
• MDCT of the breast.
• Mesenchymal stem cells in cancer: tumor-associated fibroblasts and cell-based delivery vehicles.
• Meta-analysis: Convenient assumptions and inconvenient truth.
• Monitoring the mechanically ventilated patient.
• Not just right experience: Is it influenced by feelings of guilt?
• Orthodontic treatment of TMJ disc displacement with pain: an 18 year follow-up.
• Paranasal sinuses anatomic variants: 64-slice CT evaluation.
• Perioral dermatitis after dental filling in a 12-year-old girl: involvement of cholinergic system in skin neuroinflammation?
• Persistence of regenerative myogenesis in spite of down-regulation of activity-dependent genes in long-term denervated rat muscle.
• Post-discharge nutrition of the very low-birthweight infant: interim results of the multicentric GAMMA study.
• Prebiotic concept for infant nutrition.
• Prolyl 3-hydroxylase 1 deficiency causes a recessive metabolic bone disorder resembling lethal/severe osteogenesis imperfecta.
• Psychopathology and clinical features in an Italian sample of patients with myofascial and temporomandibular joint pain: preliminary data.
• Recognition of category-related visual stimuli in Parkinson's disease: before and after pharmacological treatment.
• Somatotype in elderly type 2 diabetes patients.
• Sperm binding glycoprotein (SBG) produces calcium and bicarbonate dependent alteration of acrosome morphology and protein tyrosine phosphorylation on boar sperm.
• The "open lung" compromise.
• Tumor irradiation increases the recruitment of circulating mesenchymal stem cells into the tumor microenvironment.
• Tumor-specific tRNA modifications in mouse plasmacytomas and other tumors.
• Y-position cysteine substitution in type I collagen (alpha1(I) R888C/p.R1066C) is associated with osteogenesis imperfecta/Ehlers-Danlos syndrome phenotype.
• [Formation & inactivation of hormones of the adrenal medulla in the organism.]
• [Sanitary and social equipment in France. Problems and perspectives.]