Tumor-specific cytotoxicity and type of cell death induced by beta-cyclodextrin benzaldehyde inclusion compound.

Tumor-specific cytotoxicity and type of cell death induced by beta-cyclodextrin benzaldehyde inclusion compound. Research Abstract Details 

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Tumor-specific cytotoxicity and type of cell death induced by beta-cyclodextrin benzaldehyde inclusion compound. Abstract Text:

Yu Liu,Hiroshi Sakagami,Ken Hashimoto,Hirotaka Kikuchi,Osamu Amano,Mariko Ishihara,Yumiko Kanda,Shiro Kunii,Mutsuyuki Kochi,Wei Zhang,Guangyan Yu,

The cytotoxicity of beta-cyclodextrin benzaldehyde inclusion compound (CDBA) against human normal and cancer cell lines was investigated. CDBA showed slightly higher cytotoxicity against human tumor cell lines, as compared to normal cells, with a tumor-specificity index of 2.2. Human myelogenous leukemia cell lines (HL-60, ML-1, KG-1) were the most sensitive to CDBA, followed by human oral squamous cell carcinoma (HSC-2, HSC-3, HSC-4) and human glioblastoma (T98G, U87MG). Human normal cells (gingival fibroblasts, pulp cells, periodontal ligament fibroblasts) were the most resistant. CDBA induced internucleosomal DNA fragmentation in HL-60 cells and caspase-3, -8, -9 activation, but to a much lesser extent than that attained by UV irradiation or actinomycin D. On the other hand, CDBA did not induce DNA fragmentation, nor caspase activation in HSC-2, HSC-4 or T98G cells. Electron microscopy demonstrated that CDBA induced the destruction of mitochondrial structure and digestion of broken organelles by secondary lysosomes in all of these cells. CDBA also increased the number of acidic organelles as judged by acridine orange staining. The present study suggests that CDBA induces autophagic cell death in cancer cell lines.

Tumor-specific cytotoxicity and type of cell death induced by beta-cyclodextrin benzaldehyde inclusion compound. Publishing Authors By Initials

Y Liu,H Sakagami,K Hashimoto,H Kikuchi,O Amano,M Ishihara,Y Kanda,S Kunii,M Kochi,W Zhang,G Yu,

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Tumor-specific cytotoxicity and type of cell death induced by beta-cyclodextrin benzaldehyde inclusion compound. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Anticancer research

VOLUME: 28

Page Numbers: 229-36

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ISSN: 0250-7005

DAY: 3

MONTH: 04

YEAR: 2008

Tumor-specific cytotoxicity and type of cell death induced by beta-cyclodextrin benzaldehyde inclusion compound. Information

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LANGUAGE: eng

NlmUniqueID: 8102988

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Grant and Affiliation Information for Tumor-specific cytotoxicity and type of cell death induced by beta-cyclodextrin benzaldehyde inclusion compound.

AFFILIATION: Department of Oral and Maxillofacial Surgery, Peking University School and Hospital of Stomatology, Beijing, China. liuyu4145@sina.com

Country: Greece

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MEDLINETA: Anticancer Res

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