Tumor-specific cytotoxic activity and type of cell death induced by 4-trifluoromethylimidazoles in human oral squamous cell carcinoma cell lines.

Tumor-specific cytotoxic activity and type of cell death induced by 4-trifluoromethylimidazoles in human oral squamous cell carcinoma cell lines. Research Abstract Details 

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Tumor-specific cytotoxic activity and type of cell death induced by 4-trifluoromethylimidazoles in human oral squamous cell carcinoma cell lines. Abstract Text:

Fumihiro Takekawa,Tatsuhito Nagumo,Satoru Shintani,Ken Hashimoto,Hirotaka Kikuchi,Tadashi Katayama,Mariko Ishihara,Osamu Amano,Masami Kawase,Hiroshi Sakagami,Fumihiro Takekawa,Tatsuhito Nagumo,Satoru Shintani,Ken Hashimoto,Hirotaka Kikuchi,Tadashi Katayama,Mariko Ishihara,Osamu Amano,Masami Kawase,Hiroshi Sakagami,

Fourteen 4-trifluoromethylimidazole derivatives were investigated for their cytotoxicity against three human normal cells (gingival fibroblast HGF, pulp cell HPC and periodontal ligament fibroblast HPLF) and four human tumor cell lines (oral squamous cell carcinoma HSC-2, HSC-3, HSC-4 and promyelocytic leukemia HL-60). Among these compounds, 4-trifluoromethyl-1,2-diphenylimidazole (IM5), 1-benzyl-4-trifluoromethyl-2-phenylimidazole (IM7) and 5-[1-ethoxy-2,2,2-trifluoro-1-(trifluoromethyl) ethyl]-1-methyl-2-phenyl-1H-imidazole (IM12) showed much higher cytotoxicity and tumor-specificity than the other compounds. IM5, the most potent compound, induced different types of cell death depending on the target cells. IM5 induced DNA fragmentation of oligonucleosomal units (a biochemical hallmark of apoptosis) in the HL-60 cells, but not in such a clear-cut laddering pattern in the HSC-2 cells. On the other hand, IM5 produced secondary lysosomes digesting broken organelles, without induction of internucleosomal DNA fragmentation and disappearance of cell surface microvilli in the HSC-4 cells, even though the HSC-2 and HSC-4 cells showed comparable sensitivity to IM5. These data suggest that the type of cell death is determined by the type of target cells, but not by the drug-sensitivity of the cells.

Tumor-specific cytotoxic activity and type of cell death induced by 4-trifluoromethylimidazoles in human oral squamous cell carcinoma cell lines. Publishing Authors By Initials

F Takekawa,T Nagumo,S Shintani,K Hashimoto,H Kikuchi,T Katayama,M Ishihara,O Amano,M Kawase,H Sakagami,F Takekawa,T Nagumo,S Shintani,K Hashimoto,H Kikuchi,T Katayama,M Ishihara,O Amano,M Kawase,H Sakagami,

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MEDLINE DATE: 2007 Nov-Dec

Tumor-specific cytotoxic activity and type of cell death induced by 4-trifluoromethylimidazoles in human oral squamous cell carcinoma cell lines. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Anticancer research

VOLUME: 27

Page Numbers: 4065-9

Journal Abbreviation: Anticancer Res.

ISSN: 0250-7005

DAY: 29

MONTH: 01

YEAR: 2008

Tumor-specific cytotoxic activity and type of cell death induced by 4-trifluoromethylimidazoles in human oral squamous cell carcinoma cell lines. Information

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LANGUAGE: eng

NlmUniqueID: 8102988

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Grant and Affiliation Information for Tumor-specific cytotoxic activity and type of cell death induced by 4-trifluoromethylimidazoles in human oral squamous cell carcinoma cell lines.

AFFILIATION: Division of Pharmacology, Meikai University School of Dentistry, Sakado, Saitama 350-0283, Japan.

Country: Greece

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MEDLINETA: Anticancer Res

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