[Tumor necrosis factor and nitric oxide in the protective heat stress model]

[Tumor necrosis factor and nitric oxide in the protective heat stress model] Research Abstract Details 

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[Tumor necrosis factor and nitric oxide in the protective heat stress model] Abstract Text:

Bin Wang,Yao Liu,Bingde Luo,

OBJECTIVE: To investigate the variation and the effect of TNF and NO in the process of the creation of protective heat stress model and provide more thoretical basis. METHODS: The rats were properly treated with heat and then the serum was separated. Radioimmunoassay and nitrate reductase assay were employed to measure the concentration of TNF and NO at different time between 0 h and 24 h after heat stress respectively. RESULTS: Compared with the control, the concentration of TNF increased significantly 2 h, 4 h, 8 h, 12 h after heat stress, of which 2 h, 12 h(P < 0.05), 4 h, 8 h(P < 0.01), but no significant changes 0 h, 24 h after heat stress. The concentration reached the peak 4 h after heat stress[(3.35 +/- 0.20) ng/ml] and increased significantly than 0 h, 2 h, 8 h, 12 h, 24 h after heat stress(P < 0.01, P < 0.05). 24 h after heat stress it recovered to normal standard. Compared with the control, the concentration of NO was higher 2 h, 4 h, 8 h, 12 h, 24 h after heat stress(P < 0.05), but no significance at 0 h. The concentration amounted to peak 8 h after heat stress[(108.21 +/- 27.89) mumol/L] and increased than 0 h, 2 h, 4 h after heat stress(P < 0.01). After 8 h it began to decrease continuously in heat stress group, however it was higher 24 h after heat stress than control. CONCLUSION: TNF and NO played an important role in the process of the creation of protective heat stress model.

[Tumor necrosis factor and nitric oxide in the protective heat stress model] Publishing Authors By Initials

B Wang,Y Liu,B Luo,

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[Tumor necrosis factor and nitric oxide in the protective heat stress model] Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Zhonghua lao dong wei sheng zhi ye bing za zhi = Z

VOLUME: 20

Page Numbers: 13-5

Journal Abbreviation: Zhonghua Lao Dong Wei Sheng Zh

ISSN: 1001-9391

DAY: 25

MONTH: Feb

YEAR: 2002

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LANGUAGE: chi

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AFFILIATION: Department of Tropical Military Hygiene, First Military Medical University, Guangzhou 510515, China.

Country: China

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MEDLINETA: Zhonghua Lao Dong Wei Sheng Zh

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