Tumor immunoediting and immunosculpting pathways to cancer progression.

Tumor immunoediting and immunosculpting pathways to cancer progression. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Tumor immunoediting and immunosculpting pathways to cancer progression. Abstract Text:

Jennifer M Reiman,Maciej Kmieciak,Masoud H Manjili,Keith L Knutson,

Recent studies have suggested that a natural function of the immune system is to respond and destroy aberrant, dysfunctional cells by a process called immunosurveillance. These studies also suggest that the tumors that arise despite immunosurveillance have been immunosculpted by the immune system. The purported abilities of tumors to induce immune tolerance and suppression, the increased pathogenic behavior of the tumor cells following exposure to immune effectors and the loss of immunogenicity (i.e. immunoediting) often observed in advanced stage tumors could be the result of immunosculpting. In some cases, these immunosculpting features may be permanent and irreversible. However, in other cases, reversible epigenetic mechanisms may underlie the immune resistant tumor phenotype. Regardless, these immune-induced alterations could contribute to cancer pathogenesis. Understanding the mechanisms by which tumors evade immunity will be important for disease prevention and therapeutics.

Tumor immunoediting and immunosculpting pathways to cancer progression. Publishing Authors By Initials

JM Reiman,M Kmieciak,MH Manjili,KL Knutson,

For similar biological phenomena, cell phenomena, and immunity: immunity: tumor escape research abstracts see: biological phenomena, cell phenomena, and immunity: immunity: tumor escape research

PUBMED ID PMID:

MEDLINE DATE:

Tumor immunoediting and immunosculpting pathways to cancer progression. Journal Published:

PUBLICATION TYPE: Review

Journal: Seminars in cancer biology

VOLUME: 17

Page Numbers: 275-87

Journal Abbreviation: Semin. Cancer Biol.

ISSN: 1044-579X

DAY: 26

MONTH: 06

YEAR: 2007

Tumor immunoediting and immunosculpting pathways to cancer progression. Information

Number of References: 150

LANGUAGE: eng

NlmUniqueID: 9010218

Tumor immunoediting and immunosculpting pathways to cancer progression. Keywords Mesh Terms:

KEYWORDS: Tumor Escape

MESH TERMS: immunology

Chemical & Substance for Abstract: Tumor immunoediting and immunosculpting pathways to cancer progression. Information

Substance Name: Antigens, Neoplasm

Registry Number: 0

Grant and Affiliation Information for Tumor immunoediting and immunosculpting pathways to cancer progression.

AFFILIATION: Department of Immunology, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, United States.

Country: England

AGENCY: United States NCI

GRANT: R01-CA113861

ACRONYM: CA

MEDLINETA: Semin Cancer Biol

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Tumor immunoediting and immunosculpting pathways to cancer progression Related Publications

• An HLA-DR-degenerate epitope pool detects insulin-like growth factor binding protein 2-specific immunity in patients with cancer.
• An evaluation of the effectiveness as a caries control measure of the topical application of solutions of fluorides.
• Application of pretesting in health education.
• Application of pretesting in health education.
• Chronic benzene poisoning.
• Contingent responses of mothers and peers to indirect and direct aggression in preschool and school-aged children.
• Current status of investigations into the relationship of fluorine and dental health.
• Deaf cultural identity of adolescents with and without cochlear implants.
• Effect of topically applied zinc chloride and potassium ferrocyanide on dental caries experience.
• Evaluating A.P.H.A. Exhibits.
• Evaluating A.P.H.A. exhibits.
• Evaluation of the use of fluorine as a caries control measure; the effect of topically applied fluorides.
• Individual differences in insular sensitivity during loss: anticipation predict avoidance learning.
• Liposarcoma of the mediastinum; report of a case with associated lipomas of the mediastinum and subcutaneous tissues.
• Maternal depression and trait anger as risk factors for escalated physical discipline.
• Medical security in Sweden.
• Motivation, perception and attitude change.
• Present status of preventive procedures.
• Renal infection after ileal conduit urinary diversion. An autopsy study.
• Simplified Procedure for the Collection of Basic Data for Dental Program Planning and Appraisal.
• Sodium fluoride solutions; technic for application to the teeth.
• Sodium fluoride solutions; technic for application to the teeth.
• Sweden's new health insurance scheme.
• The endogenous danger signal, crystalline uric acid, signals for enhanced antibody immunity.
• The makings of a good meeting.
• The nationwide topical fluoride demonstration program.
• The use of fluorides in the control of dental caries.
• Tumor immunoediting and immunosculpting pathways to cancer progression.
• Valence and salience contribute to nucleus accumbens activation.
• [Not Available.]