TT virus infection among Egyptian patients with hepatocellular carcinoma.

TT virus infection among Egyptian patients with hepatocellular carcinoma. Research Abstract Details 

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TT virus infection among Egyptian patients with hepatocellular carcinoma. Abstract Text:

Howayda Hassoba,Moushira Mahmoud,Hanaa Fahmy,Ola Leheta,Amal Sayed,Amal Fathy,Abdelhamid Serwah,Amr Abbas,Zohair Nooman,Fawzy Attia,Yuri Khudyakov,

Hepatitis B and C viruses (HBV and HCV) have been associated with hepatocellular carcinoma (HCC). Recently, a novel DNA virus was isolated from a patient with posttransfusion hepatitis of unknown etiology and designated TT virus (TTV). To examine whether this virus is associated with HCC, we investigated sera from 82 Egyptian patients with histopathologically-diagnosed HCC. All subjects underwent serological investigations for detection of hepatitis B surface antigen (HbsAg), hepatitis B core antibody (HbcAb) and anti-HCV. Detection of TTV-DNA was performed by semi-nested polymerase chain reaction (PCR) using TTV-specific primers. TTV-DNA was detected in 28% of the patients. Age, gender, risk factors and biochemical liver functions did not significantly differ between TTV-DNA positive and negative patients. TTV was detected in 27.1% of patients with HCV-HCC, 25% of HBV-HCC, 66.7% of dual HCV and HBV infection and 40% of those with non-B, non-C-HCC (NBNC-HCC). It is concluded that, in this the cohort of Egyptian patients with HCC, TTV infection is common and is not associated with HCV, HBV, NBNC-HCC, history of schistosomiasis or blood transfusion.

TT virus infection among Egyptian patients with hepatocellular carcinoma. Publishing Authors By Initials

H Hassoba,M Mahmoud,H Fahmy,O Leheta,A Sayed,A Fathy,A Serwah,A Abbas,Z Nooman,F Attia,Y Khudyakov,

For similar viruses: dna viruses: anellovirus: torque teno virus research abstracts see: viruses: dna viruses: anellovirus: torque teno virus research

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TT virus infection among Egyptian patients with hepatocellular carcinoma. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: The Egyptian journal of immunology / Egyptian Asso

VOLUME: 10

Page Numbers: 9-16

Journal Abbreviation: Egypt J Immunol

ISSN: 1110-4902

DAY: 11

MONTH: 02

YEAR: 2003

TT virus infection among Egyptian patients with hepatocellular carcinoma. Information

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LANGUAGE: eng

NlmUniqueID: 9816016

TT virus infection among Egyptian patients with hepatocellular carcinoma. Keywords Mesh Terms:

KEYWORDS: Torque teno virus

MESH TERMS: pathogenicity

Chemical & Substance for Abstract: TT virus infection among Egyptian patients with hepatocellular carcinoma. Information

Substance Name: DNA, Viral

Registry Number: 0

Grant and Affiliation Information for TT virus infection among Egyptian patients with hepatocellular carcinoma.

AFFILIATION: Department of Clinical Pathology, Faculty of Medicine, Suez Canal University, Egypt.

Country: Egypt

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MEDLINETA: Egypt J Immunol

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