Tryptophan orientation in model lipid membranes.

Tryptophan orientation in model lipid membranes. Research Abstract Details 

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Tryptophan orientation in model lipid membranes. Abstract Text:

Elin K ,Christina E B Caesar,Bo Albinsson,Per Lincoln,Bengt ,

Tryptophans in membrane proteins display strong preference for the lipid membrane interface and are important for anchoring proteins at the proper longitudinal level. Linear dichroism spectroscopy on indoles in shear-deformed liposomes has been used to show that this positioning is accompanied by an intrinsically adopted orientation, also observed for tryptophans in membrane-bound peptides. Similarities in orientation of different indoles suggest that tryptophan will adopt this orientation independent of the protein it is part of. From the orientation of indole electronic transition moments L(a), L(b) and B(b), a binding model is proposed where the indole long axis is approximately 60-65 degrees from the membrane normal and the indole plane is at an oblique angle. We propose that dipole-dipole interactions and steric constraints in the membrane hydrocarbon region determine positioning and orientation of tryptophans whereas hydrogen bonding and cation-pi interactions with lipid head-groups, though contributing to the membrane affinity of indoles, are less important.

Tryptophan orientation in model lipid membranes. Publishing Authors By Initials

EK ,CE Caesar,B Albinsson,P Lincoln,B ,

For similar biomedical and dental materials: membranes, artificial: liposomes: unilamellar liposomes research abstracts see: biomedical and dental materials: membranes, artificial: liposomes: unilamellar liposomes research

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Tryptophan orientation in model lipid membranes. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Biochemical and biophysical research communication

VOLUME: 361

Page Numbers: 645-50

Journal Abbreviation: Biochem. Biophys. Res. Commun.

ISSN: 0006-291X

DAY: 31

MONTH: 07

YEAR: 2007

Tryptophan orientation in model lipid membranes. Information

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LANGUAGE: eng

NlmUniqueID: 372516

Tryptophan orientation in model lipid membranes. Keywords Mesh Terms:

KEYWORDS: Unilamellar Liposomes

MESH TERMS: chemistry

Chemical & Substance for Abstract: Tryptophan orientation in model lipid membranes. Information

Substance Name: Tryptophan

Registry Number: 73-22-3

Grant and Affiliation Information for Tryptophan orientation in model lipid membranes.

AFFILIATION: Department of Chemical and Biological Engineering/Physical Chemistry, Chalmers University of Technology, Kemivägen 10, S-412 96 Gothenburg, Sweden. eline@chalmers.se

Country: United States

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MEDLINETA: Biochem Biophys Res Commun

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