Tryptathionine bridges in peptide synthesis.

Tryptathionine bridges in peptide synthesis. Research Abstract Details 

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Tryptathionine bridges in peptide synthesis. Abstract Text:

Jonathan P May,David M Perrin,Jonathan P May,David M Perrin,

The tryptathionine linkage is a crosslink formed between tryptophan and cysteine. This feature is characteristic of the bicyclic peptides: the phallotoxins and the amatoxins. These peptides both bind to protein folds of their respective targets (F-actin and RNA pol II, respectively) with extremely high affinities. Studies on these peptides have shown that the tryptathionine crosslink is essential for this binding affinity. Tryptathionines have been investigated for many years and several syntheses exist for their formation. In this review, we report on the various methodologies employed in tryptathionine synthesis, and discuss some of the advantages and disadvantages associated with each of them.

Tryptathionine bridges in peptide synthesis. Publishing Authors By Initials

JP May,DM Perrin,JP May,DM Perrin,

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Tryptathionine bridges in peptide synthesis. Journal Published:

PUBLICATION TYPE: Review

Journal: Biopolymers

VOLUME: 88

Page Numbers: 714-24

Journal Abbreviation: Biopolymers

ISSN: 0006-3525

DAY: 12

MONTH: 09

YEAR: 2007

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LANGUAGE: eng

NlmUniqueID: 372525

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AFFILIATION: Department of Chemistry, University of British Columbia, 2036 Main Mall, Vancouver, BC, V6T 1Z1, Canada.

Country: United States

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MEDLINETA: Biopolymers

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