Trypanosoma congolense: paraoxonase 1 prolongs survival of infected mice.

Trypanosoma congolense: paraoxonase 1 prolongs survival of infected mice. Research Abstract Details 

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Trypanosoma congolense: paraoxonase 1 prolongs survival of infected mice. Abstract Text:

Kum Kum Bhasin,Janet M Yu,Aaron Tward,Diana Shih,David A Campbell,Aldons J Lusis,

In vitro studies have suggested that a fraction of human high density lipoprotein (HDL), termed trypanosome lysis factor (TLF), can protect against trypanosome infection. We examined the involvement of two proteins located in the TLF fraction, apolipoprotein A-II (apoA-II) and paraoxonase 1 (PON1), against trypanosome infection. To test whether PON1 is involved in trypanosome resistance, we infected human PON1 transgenic mice, PON1 knockout mice, and wild-type mice with Trypanosoma congolense. When challenged with the same dosage of trypanosomes, mice overexpressing PON1 lived significantly longer than wild-type mice, and mice deficient in PON1 lived significantly shorter. In contrast, mice overexpressing another HDL associated protein, apoA-II, had the same survival as wild-type mice. Together, these data suggest that PON1 provides protection against trypanosome infection. In vitro studies using T. brucei brucei indicated that HDL particles containing PON1 and those depleted of PON1 did not differ in their lysis ability, suggesting that protection by PON1 is indirect. Our data are consistent with an in vivo role of HDL protection against trypanosome infection.

Trypanosoma congolense: paraoxonase 1 prolongs survival of infected mice. Publishing Authors By Initials

KK Bhasin,JM Yu,A Tward,D Shih,DA Campbell,AJ Lusis,

For similar parasitic diseases: protozoan infections: sarcomastigophora infections: mastigophora infections: trypanosomiasis: trypanosomiasis, african research abstracts see: parasitic diseases: protozoan infections: sarcomastigophora infections: mastigophora infections: trypanosomiasis: trypanosomiasis, african research

PUBMED ID PMID:

MEDLINE DATE:

Trypanosoma congolense: paraoxonase 1 prolongs survival of infected mice. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Experimental parasitology

VOLUME: 114

Page Numbers: 240-5

Journal Abbreviation: Exp. Parasitol.

ISSN: 0014-4894

DAY: 8

MONTH: 05

YEAR: 2006

Trypanosoma congolense: paraoxonase 1 prolongs survival of infected mice. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 370713

Trypanosoma congolense: paraoxonase 1 prolongs survival of infected mice. Keywords Mesh Terms:

KEYWORDS: Trypanosomiasis, African

MESH TERMS: immunology

Chemical & Substance for Abstract: Trypanosoma congolense: paraoxonase 1 prolongs survival of infected mice. Information

Substance Name: PON1 protein, human

Registry Number: EC 3.1.8.1

Grant and Affiliation Information for Trypanosoma congolense: paraoxonase 1 prolongs survival of infected mice.

AFFILIATION: Department of Medicine, University of California, Los Angeles, CA 90095, USA.

Country: United States

AGENCY: United States NIGMS

GRANT: T32-GM08243

ACRONYM: GM

MEDLINETA: Exp Parasitol

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