Truncation of Plasmodium berghei merozoite surface protein 8 does not affect in vivo blood-stage development.

Truncation of Plasmodium berghei merozoite surface protein 8 does not affect in vivo blood-stage development. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Truncation of Plasmodium berghei merozoite surface protein 8 does not affect in vivo blood-stage development. Abstract Text:

Merozoite surface protein 8 (MSP8) has shown promise as a vaccine candidate in the Plasmodium yoelii rodent malaria model and has a proposed role in merozoite invasion of erythrocytes. However, the temporal expression and localisation of MSP8 are unusual for a merozoite antigen. Moreover, in Plasmodium falciparum the MSP8 gene could be disrupted with no apparent effect on invitro growth. To address the invivo function of full-length MSP8, we truncated MSP8 in the rodent parasite Plasmodium berghei. PbDeltaMSP8 disruptant parasites displayed a normal blood-stage growth rate but no increase in reticulocyte preference, a phenomenon observed in P. yoelii MSP8 vaccinated mice. Expression levels of erythrocyte surface antigens were similar in P. berghei wild-type and PbDeltaMSP8-infected erythrocytes, suggesting that a parasitophorous vacuole function for MSP8 does not involve global trafficking of such antigens. These data demonstrate that a full-length membrane-associated form of PbMSP8 is not essential for blood-stage growth.

Truncation of Plasmodium berghei merozoite surface protein 8 does not affect in vivo blood-stage development. Publishing Authors By Initials

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Truncation of Plasmodium berghei merozoite surface protein 8 does not affect in vivo blood-stage development. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Molecular and biochemical parasitology

VOLUME: 159

Page Numbers: 69-72

Journal Abbreviation: Mol. Biochem. Parasitol.

ISSN: 0166-6851

DAY: 14

MONTH: 02

YEAR: 2008

Truncation of Plasmodium berghei merozoite surface protein 8 does not affect in vivo blood-stage development. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8006324

Truncation of Plasmodium berghei merozoite surface protein 8 does not affect in vivo blood-stage development. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Truncation of Plasmodium berghei merozoite surface protein 8 does not affect in vivo blood-stage development. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Truncation of Plasmodium berghei merozoite surface protein 8 does not affect in vivo blood-stage development.

AFFILIATION: The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC 3050, Australia.

Country: Netherlands

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Mol Biochem Parasitol

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Truncation of Plasmodium berghei merozoite surface protein 8 does not affect in vivo blood-stage development Related Publications

• A rapid rosin-celloidin-paraffin method for embedding tissues.
• Alcohol Deranges Hepatic Lipid Metabolism via Altered Transcriptional Regulation.
• Alcohol and lipid metabolism.
• Analysis of visual field progression in glaucoma.
• Antibiotic sensitivity of staphylococci from noses of veterinary surgeons and farmers.
• Association of the aldehyde dehydrogenase 2 promoter polymorphism with alcohol consumption and reactions in an American Jewish population.
• CRALBP ligand and protein interactions.
• Carboxyethylpyrrole adducts, age-related macular degeneration and neovascularization.
• Evidence for a common role for the serine-type Plasmodium falciparum serine repeat antigen proteases: implications for vaccine and drug design.
• Evidence that invasion-inhibitory antibodies specific for the 19-kDa fragment of merozoite surface protein-1 (MSP-1 19) can play a protective role against blood-stage Plasmodium falciparum infection in individuals in a malaria endemic area of Africa.
• Genetic, age and light mediated effects on crystallin protein expression in the retina.
• Loss of sexual differentiation of rat hepatocytes in short-term culture.
• MSP1(19) miniproteins can serve as targets for invasion inhibitory antibodies in Plasmodium falciparum provided they contain the correct domains for cell surface trafficking.
• Metaphen and mercurochrome intravenously for sepsis.
• Metastasis in hamsters implanted with emulsified and with solid pieces of a mixed-cell sarcoma.
• More sensitive assay to detect drug-resistant HIV.
• Pathogenesis of alcoholic liver disease: newer mechanisms of injury.
• Retinal pigment epithelium lipofuscin proteomics.
• Targets of tyrosine nitration in diabetic rat retina.
• The cleansing of root canals.
• Towards a Vaccine against Plasmodium vivax Malaria.
• Truncation of Plasmodium berghei merozoite surface protein 8 does not affect in vivo blood-stage development.
• Will histone deacetylase inhibitors require combination with other agents to fulfil their therapeutic potential?