Truncation and non-natural amino acid substitution studies on HTLV-I protease hexapeptidic inhibitors.

Truncation and non-natural amino acid substitution studies on HTLV-I protease hexapeptidic inhibitors. Research Abstract Details 

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Truncation and non-natural amino acid substitution studies on HTLV-I protease hexapeptidic inhibitors. Abstract Text:

Jeffrey-Tri Nguyen,Meihui Zhang,Henri-Obadja Kumada,Ayako Itami,Keiji Nishiyama,Tooru Kimura,Maosheng Cheng,Yoshio Hayashi,Yoshiaki Kiso,Jeffrey-Tri Nguyen,Meihui Zhang,Henri-Obadja Kumada,Ayako Itami,Keiji Nishiyama,Tooru Kimura,Maosheng Cheng,Yoshio Hayashi,Yoshiaki Kiso,

The culprit behind adult T-cell leukemia, myelopathy/tropical paraparesis, and a plethora of inflammatory diseases is the human T-cell leukemia virus type 1 (HTLV-I). We recently unveiled a potent hexapeptidic HTLV-I protease inhibitor, KNI-10166, composed mostly of natural amino acid residues. Herein, we report the derivation of potent tetrapeptidic inhibitor KNI-10516, possessing only non-natural amino acid residues.

Truncation and non-natural amino acid substitution studies on HTLV-I protease hexapeptidic inhibitors. Publishing Authors By Initials

JT Nguyen,M Zhang,HO Kumada,A Itami,K Nishiyama,T Kimura,M Cheng,Y Hayashi,Y Kiso,JT Nguyen,M Zhang,HO Kumada,A Itami,K Nishiyama,T Kimura,M Cheng,Y Hayashi,Y Kiso,

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Truncation and non-natural amino acid substitution studies on HTLV-I protease hexapeptidic inhibitors. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Bioorganic & medicinal chemistry letters

VOLUME: 18

Page Numbers: 366-70

Journal Abbreviation: Bioorg. Med. Chem. Lett.

ISSN: 1464-3405

DAY: 24

MONTH: 10

YEAR: 2007

Truncation and non-natural amino acid substitution studies on HTLV-I protease hexapeptidic inhibitors. Information

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LANGUAGE: eng

NlmUniqueID: 9107377

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Grant and Affiliation Information for Truncation and non-natural amino acid substitution studies on HTLV-I protease hexapeptidic inhibitors.

AFFILIATION: Department of Medicinal Chemistry, Center for Frontier Research in Medicinal Science and 21st Century COE Program, Kyoto Pharmaceutical University, Yamashina-ku, Kyoto 607-8412, Japan.

Country: England

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MEDLINETA: Bioorg Med Chem Lett

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