TRPM8 Axonal expression is decreased in painful human teeth with irreversible pulpitis and cold hyperalgesia.

TRPM8 Axonal expression is decreased in painful human teeth with irreversible pulpitis and cold hyperalgesia. Research Abstract Details 

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TRPM8 Axonal expression is decreased in painful human teeth with irreversible pulpitis and cold hyperalgesia. Abstract Text:

Lisa T Alvarado,Griffin M Perry,Kenneth M Hargreaves,Michael A Henry,Lisa T Alvarado,Griffin M Perry,Kenneth M Hargreaves,Michael A Henry,

Pulpitis pain might be triggered by a cold stimulus, yet the cellular mechanisms responsible for this phenomenon are largely unknown. One possible mechanism involves the direct activation of cold-responsive thermoreceptors. The purpose of this study was to evaluate the possible role of the TRPM8 thermoreceptor in cold-mediated noxious pulpal pain mechanisms by comparing expression patterns in pulpal nerves from healthy control molars to cold-sensitive painful molars with irreversible pulpitis. Samples were identically processed with the indirect immunofluorescence method, and images were obtained with confocal microscopy. The immunofluorescence intensity and area occupied by TRPM8 within N52/PGP9.5-identified nerve fibers were quantified. Results showed that relative to normal samples, TRPM8 nerve area expression was significantly less in the cold-sensitive painful samples (34.9% vs 8%, P <0.03), but with no significant difference in immunofluorescence intensity between the 2 groups. These results suggest that TRPM8 is most likely not involved in cold-mediated noxious pulpal pain mechanisms.

TRPM8 Axonal expression is decreased in painful human teeth with irreversible pulpitis and cold hyperalgesia. Publishing Authors By Initials

LT Alvarado,GM Perry,KM Hargreaves,MA Henry,LT Alvarado,GM Perry,KM Hargreaves,MA Henry,

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TRPM8 Axonal expression is decreased in painful human teeth with irreversible pulpitis and cold hyperalgesia. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of endodontics

VOLUME: 33

Page Numbers: 1167-71

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ISSN: 0099-2399

DAY: 16

MONTH: 08

YEAR: 2007

TRPM8 Axonal expression is decreased in painful human teeth with irreversible pulpitis and cold hyperalgesia. Information

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LANGUAGE: eng

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Grant and Affiliation Information for TRPM8 Axonal expression is decreased in painful human teeth with irreversible pulpitis and cold hyperalgesia.

AFFILIATION: Department of Endodontics, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229-3900, USA.

Country: United States

AGENCY: United States NIDCR

GRANT: DE 015576

ACRONYM: DE

MEDLINETA: J Endod

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