Trophoblast-macrophage interactions: a regulatory network for the protection of pregnancy.

Trophoblast-macrophage interactions: a regulatory network for the protection of pregnancy. Research Abstract Details 

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Trophoblast-macrophage interactions: a regulatory network for the protection of pregnancy. Abstract Text:

Stefan Fest,Paulomi B Aldo,V M Abrahams,I Visintin,A Alvero,R Chen,S L Chavez,R Romero,G Mor,

PROBLEM: Macrophages are one of the first immune cells observed at the implantation site. Their presence has been explained as the result of an immune response toward paternal antigens. The mechanisms regulating monocyte migration and differentiation at the implantation site are largely unknown. In the present study, we demonstrate that trophoblast cells regulate monocyte migration and differentiation. We propose that trophoblast cells 'educate' monocytes/macrophages to create an adequate environment that promote trophoblast survival. METHOD OF STUDY: CD14(+) monocytes were isolated from peripheral blood using magnetic beads. Co-culture experiments were conducted using a two-chamber system. Monocytes were stimulated with lipopolysaccharide (LPS) and cytokine levels were determined using multiplex cytokine detecting assay. RESULTS: Trophoblast cells increase monocyte migration and induce a significant increase in the secretion and production of the pro-inflammatory cytokines [interleukin-6 (IL-6), IL-8, tumor necrosis factor-alpha] and chemokines (growth-related oncogen-alpha, monocyte chemoattractant protein-1, macrophage inflammatory protein-1beta, RANTES). Furthermore, the response of monocytes to LPS was different in monocytes pre-exposed to trophoblast cells. CONCLUSION: The results of this study suggest that trophoblast cells are able to recruit and successfully educate monocytes to produce and secrete a pro-inflammatory cytokine and chemokine profile supporting its growth and survival. Furthermore we demonstrate that trophoblast cells can modulate monocytes response to bacterial stimuli.

Trophoblast-macrophage interactions: a regulatory network for the protection of pregnancy. Publishing Authors By Initials

S Fest,PB Aldo,VM Abrahams,I Visintin,A Alvero,R Chen,SL Chavez,R Romero,G Mor,

For similar cells: trophoblasts research abstracts see: cells: trophoblasts research

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Trophoblast-macrophage interactions: a regulatory network for the protection of pregnancy. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Intr

Journal: American journal of reproductive immunology (New Y

VOLUME: 57

Page Numbers: 55-66

Journal Abbreviation: Am. J. Reprod. Immunol.

ISSN: 1046-7408

DAY: 3

MONTH: Jan

YEAR: 2007

Trophoblast-macrophage interactions: a regulatory network for the protection of pregnancy. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8912860

Trophoblast-macrophage interactions: a regulatory network for the protection of pregnancy. Keywords Mesh Terms:

KEYWORDS: Trophoblasts

MESH TERMS: secretion

Chemical & Substance for Abstract: Trophoblast-macrophage interactions: a regulatory network for the protection of pregnancy. Information

Substance Name: Lipopolysaccharides

Registry Number: 0

Grant and Affiliation Information for Trophoblast-macrophage interactions: a regulatory network for the protection of pregnancy.

AFFILIATION: Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, Yale University, New Haven, CT 06520, USA.

Country: Denmark

AGENCY: United States NICHD

GRANT: R01 HD049446-01

ACRONYM: HD

MEDLINETA: Am J Reprod Immunol

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