[Trophoblast invasion in pre-eclampsia]

[Trophoblast invasion in pre-eclampsia] Research Abstract Details 

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[Trophoblast invasion in pre-eclampsia] Abstract Text:

F Reister,W Heyl,P Kaufmann,W Rath,

It is generally accepted that insufficient invasion of trophoblast cells into the myometrial portions of the spiral arteries is thought to play a crucial role in the development of preeclampsia. As a consequence, uteroplacental vessels fail to undergo adaptive changes which are imperative to provide a sufficient blood supply to the placenta. Consecutive placental hypoxia is supposed to cause secretion/shedding of still unidentified placental metabolites resulting in different forms of pregnancy-induced hypertension. This review presents published data concerning the causes of insufficient trophoblast invasion in preeclampsia. Expression of HLA-G by extravillous trophoblast cells seems to be altered, resulting in activation of the maternal immune system. The pattern of integrin expression as well as the secretion of proteases is reported to be disturbed, which could lead to a reduced invasive potential of the trophoblast cells. Recent data indicate a pathophysiological role of NK-cells and macrophages in the altered trophoblast invasion. Also angiotensinogen Thr235 polymorphism seems to alter early physiologic changes in spiral arteries. In summary, preeclampsia seems to be induced by a multifactorial disturbance of trophoblast invasiveness which is characterized by reduced invasiveness of the trophoblast cells themselves and by an activated maternal immune response blocking the invasion by the semiallogenic trophoblast.

[Trophoblast invasion in pre-eclampsia] Publishing Authors By Initials

F Reister,W Heyl,P Kaufmann,W Rath,

For similar cells: trophoblasts research abstracts see: cells: trophoblasts research

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[Trophoblast invasion in pre-eclampsia] Journal Published:

PUBLICATION TYPE: Review

Journal: Zentralblatt für Gynäkologie

VOLUME: 121

Page Numbers: 587-90

Journal Abbreviation: Zentralbl Gynakol

ISSN: 0044-4197

DAY: 11

MONTH: 02

YEAR: 1999

[Trophoblast invasion in pre-eclampsia] Information

Number of References: 24

LANGUAGE: ger

NlmUniqueID: 21820100

[Trophoblast invasion in pre-eclampsia] Keywords Mesh Terms:

KEYWORDS: Trophoblasts

MESH TERMS: physiology

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Grant and Affiliation Information for [Trophoblast invasion in pre-eclampsia]

AFFILIATION: Frauenklinik für Gynäkologie und Geburtshilfe, Rheinisch-Westfälischen Technischen Hochschule (RWTH) Aachen. Frank.Reister@post.rwth-aachen.de

Country: GERMANY

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MEDLINETA: Zentralbl Gynakol

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