Trivalent antigens for degranulation of mast cells.

Trivalent antigens for degranulation of mast cells. Research Abstract Details 

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Trivalent antigens for degranulation of mast cells. Abstract Text:

Richard G Posner,Dianliang Geng,Seth Haymore,James Bogert,Israel Pecht,Arieh Licht,Paul B Savage,

Degranulation of basophils and mast cells plays a central role in allergic reactions. Degranulation is a response to cell surface receptor aggregation caused by association of receptors with antibodies bound to multivalent antigens. Tools used in studying this process have included small-molecule divalent antigens, but they suffer from weak signaling apparently due to small aggregate size. We have prepared trivalent antigens that allow formation of larger aggregates and potent responses from mast cells.

Trivalent antigens for degranulation of mast cells. Publishing Authors By Initials

RG Posner,D Geng,S Haymore,J Bogert,I Pecht,A Licht,PB Savage,

For similar biochemical phenomena, metabolism, and nutrition: biochemical phenomena: molecular structure research abstracts see: biochemical phenomena, metabolism, and nutrition: biochemical phenomena: molecular structure research

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Trivalent antigens for degranulation of mast cells. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Organic letters

VOLUME: 9

Page Numbers: 3551-4

Journal Abbreviation: Org. Lett.

ISSN: 1523-7060

DAY: 11

MONTH: 08

YEAR: 2007

Trivalent antigens for degranulation of mast cells. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 100890393

Trivalent antigens for degranulation of mast cells. Keywords Mesh Terms:

KEYWORDS: Molecular Structure

MESH TERMS: physiology

Chemical & Substance for Abstract: Trivalent antigens for degranulation of mast cells. Information

Substance Name: Hexosaminidases

Registry Number: EC 3.2.1.-

Grant and Affiliation Information for Trivalent antigens for degranulation of mast cells.

AFFILIATION: Department of Computational Biology, Translational Genomics Research Institute, Phoenix, Arizona 85004, USA.

Country: United States

AGENCY: United States NIAID

GRANT: AI35997

ACRONYM: AI

MEDLINETA: Org Lett

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