tris-Azaaromatic quaternary ammonium salts: Novel templates as antagonists at nicotinic receptors mediating nicotine-evoked dopamine release.

tris-Azaaromatic quaternary ammonium salts: Novel templates as antagonists at nicotinic receptors mediating nicotine-evoked dopamine release. Research Abstract Details 

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tris-Azaaromatic quaternary ammonium salts: Novel templates as antagonists at nicotinic receptors mediating nicotine-evoked dopamine release. Abstract Text:

Guangrong Zheng,Sangeetha P Sumithran,Agripina G Deaciuc,Linda P Dwoskin,Peter A Crooks,Guangrong Zheng,Sangeetha P Sumithran,Agripina G Deaciuc,Linda P Dwoskin,Peter A Crooks,Guangrong Zheng,Sangeetha P Sumithran,Agripina G Deaciuc,Linda P Dwoskin,Peter A Crooks,

A series of tris-azaaromatic quaternary ammonium salts has been synthesized and evaluated for their ability to inhibit neuronal nicotinic acetylcholine receptors (nAChRs) mediating nicotine-evoked [(3)H]dopamine release from superfused rat striatal slices and for inhibition of [(3)H]nicotine and [(3)H]methyllycaconitine binding to whole rat brain membranes. The 3-picolinium compound 1,3,5-tri-{5-[1-(3-picolinium)]-pent-1-ynyl}benzene tribromide (tPy3PiB), 3b, exhibited high potency and selectivity for nAChR subtypes mediating nicotine-evoked [(3)H]dopamine release with an IC(50) of 0.2nM and I(max) of 67%.

tris-Azaaromatic quaternary ammonium salts: Novel templates as antagonists at nicotinic receptors mediating nicotine-evoked dopamine release. Publishing Authors By Initials

G Zheng,SP Sumithran,AG Deaciuc,LP Dwoskin,PA Crooks,G Zheng,SP Sumithran,AG Deaciuc,LP Dwoskin,PA Crooks,G Zheng,SP Sumithran,AG Deaciuc,LP Dwoskin,PA Crooks,

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tris-Azaaromatic quaternary ammonium salts: Novel templates as antagonists at nicotinic receptors mediating nicotine-evoked dopamine release. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Bioorganic & medicinal chemistry letters

VOLUME: 17

Page Numbers: 6701-6

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ISSN: 0960-894X

DAY: 22

MONTH: 10

YEAR: 2007

tris-Azaaromatic quaternary ammonium salts: Novel templates as antagonists at nicotinic receptors mediating nicotine-evoked dopamine release. Information

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LANGUAGE: eng

NlmUniqueID: 9107377

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Grant and Affiliation Information for tris-Azaaromatic quaternary ammonium salts: Novel templates as antagonists at nicotinic receptors mediating nicotine-evoked dopamine release.

AFFILIATION: Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, KY 40536-0082, USA.

Country: England

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MEDLINETA: Bioorg Med Chem Lett

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