TRIM68 regulates ligand-dependent transcription of androgen receptor in prostate cancer cells.

TRIM68 regulates ligand-dependent transcription of androgen receptor in prostate cancer cells. Research Abstract Details 

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TRIM68 regulates ligand-dependent transcription of androgen receptor in prostate cancer cells. Abstract Text:

The androgen receptor (AR) is a transcription factor belonging to the family of nuclear receptors that mediate the action of androgen. AR plays an important role in normal development of the prostate, as well as in the progression of prostate cancer. AR is regulated by several posttranslational modifications, including phosphorylation, acetylation, and ubiquitination. In this study, we found that the putative E3 ubiquitin ligase TRIM68, which is preferentially expressed in prostate cancer cells, interacts with AR and enhances transcriptional activity of the AR in the presence of dihydrotestosterone. We also found that TRIM68 functionally interacts with TIP60 and p300, which act as coactivators of AR, and synergizes in the transactivation of AR. Overexpression of TRIM68 in prostate cancer cells caused an increase in secretion of prostate-specific antigen (PSA), one of the most reliable diagnostic markers for prostate cancer, whereas knockdown of TRIM68 attenuated the secretion of PSA and inhibited cell growth and colony-forming ability. Moreover, we showed that TRIM68 expression is significantly up-regulated in human prostate cancers compared with the expression in adjacent normal tissues. These results indicate that TRIM68 functions as a cofactor for AR-mediated transcription and is likely to be a novel diagnostic tool and a potentially therapeutic target for prostate cancer.

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TRIM68 regulates ligand-dependent transcription of androgen receptor in prostate cancer cells. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Cancer research

VOLUME: 68

Page Numbers: 3486-94

Journal Abbreviation: Cancer Res.

ISSN: 1538-7445

DAY: 1

MONTH: May

YEAR: 2008

TRIM68 regulates ligand-dependent transcription of androgen receptor in prostate cancer cells. Information

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LANGUAGE: eng

NlmUniqueID: 2984705

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Grant and Affiliation Information for TRIM68 regulates ligand-dependent transcription of androgen receptor in prostate cancer cells.

AFFILIATION: Department of Biochemistry, Hokkaido University Graduate School of Medicine, Sapporo, Japan.

Country: United States

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MEDLINETA: Cancer Res

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