Triggering DNAzymes with light: a photoactive C8 thioether-linked adenosine.

Triggering DNAzymes with light: a photoactive C8 thioether-linked adenosine. Research Abstract Details 

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Triggering DNAzymes with light: a photoactive C8 thioether-linked adenosine. Abstract Text:

Richard Ting,Leonard Lermer,David M Perrin,

Herein we report evidence for a light-inducible DNAzyme. In so doing, we also disclose the synthesis and photochemical properties of a novel nucleoside: 8-(2-(4-imidazolyl)ethyl-1-thio)-2'-deoxyriboadenosine (d1). The light sensitivity of (d1) was evaluated via an examination of the photoinduced reactivation of DNAzyme 8-17E from an inactive form that contained a single nucleotide (d1) modification. Restoration of DNAzyme activity results from a photoinduced reversion of (d1) to unmodified deoxyadenosine. Deuterium studies indicate that water is the source of hydrogen in the C8-H product and not the alkylthio group, suggesting that reversion of (1) to adenosine is not a consequence of simple homolysis of the C8-S bond but of an unprecedented photochemical conversion. This adenosine, which affords significant control of catalytic reactivation of a DNAzyme, may find general use in photodecaging other biological systems.

Triggering DNAzymes with light: a photoactive C8 thioether-linked adenosine. Publishing Authors By Initials

R Ting,L Lermer,DM Perrin,

For similar inorganic chemicals: electrolytes: ions: anions: sulfides research abstracts see: inorganic chemicals: electrolytes: ions: anions: sulfides research

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Triggering DNAzymes with light: a photoactive C8 thioether-linked adenosine. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of the American Chemical Society

VOLUME: 126

Page Numbers: 12720-1

Journal Abbreviation: J. Am. Chem. Soc.

ISSN: 0002-7863

DAY: 13

MONTH: Oct

YEAR: 2004

Triggering DNAzymes with light: a photoactive C8 thioether-linked adenosine. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7503056

Triggering DNAzymes with light: a photoactive C8 thioether-linked adenosine. Keywords Mesh Terms:

KEYWORDS: Sulfides

MESH TERMS: metabolism

Chemical & Substance for Abstract: Triggering DNAzymes with light: a photoactive C8 thioether-linked adenosine. Information

Substance Name: RNA

Registry Number: 63231-63-0

Grant and Affiliation Information for Triggering DNAzymes with light: a photoactive C8 thioether-linked adenosine.

AFFILIATION: Department of Chemistry, The University of British Columbia, Vancouver, BC, V6T-1Z1, Canada.

Country: United States

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MEDLINETA: J Am Chem Soc

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