Trierixin, a Novel Inhibitor of ER Stress-induced XBP1 Activation from Streptomyces sp.

Trierixin, a Novel Inhibitor of ER Stress-induced XBP1 Activation from Streptomyces sp. Research Abstract Details 

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Trierixin, a Novel Inhibitor of ER Stress-induced XBP1 Activation from Streptomyces sp. Abstract Text:

Etsu Tashiro,Naoka Hironiwa,Mitsuhiro Kitagawa,Yushi Futamura,Shin-Ichi Suzuki,Maki Nishio,Masaya Imoto,Etsu Tashiro,Naoka Hironiwa,Mitsuhiro Kitagawa,Yushi Futamura,Shin-Ichi Suzuki,Maki Nishio,Masaya Imoto,Etsu Tashiro,Naoka Hironiwa,Mitsuhiro Kitagawa,Yushi Futamura,Shin-Ichi Suzuki,Maki Nishio,Masaya Imoto,Etsu Tashiro,Naoka Hironiwa,Mitsuhiro Kitagawa,Yushi Futamura,Shin-Ichi Suzuki,Maki Nishio,Masaya Imoto,

In the course of screening for an inhibitor of ER stress-induced XBP1 activation, we isolated a new member of the triene-ansamycin group compound, trierixin, from a culture broth of Streptomyces sp. AC 654. Trierixin was purified by column chromatography on silica gel and by HPLC. The molecular formula of trierixin is C(37)H(52)N(2)O(8)S. Trierixin inhibited thapsigargin-induced XBP1-luciferase activation in HeLa/XBP1-luc cells and endogenous XBP1 splicing in HeLa cells with an IC(50) of 14 ng/ml and 19 ng/ml, respectively. Moreover, in the process of isolating trierixin, we isolated structurally related mycotrienin II and trienomycin A as inhibitors of ER stress-induced XBP1 activation from a culture broth of a trierixin-producing strain. This study provides the first observation that triene-ansamycins have a novel inhibitory effect against XBP1 activation.

Trierixin, a Novel Inhibitor of ER Stress-induced XBP1 Activation from Streptomyces sp. Publishing Authors By Initials

E Tashiro,N Hironiwa,M Kitagawa,Y Futamura,S Suzuki,M Nishio,M Imoto,E Tashiro,N Hironiwa,M Kitagawa,Y Futamura,S Suzuki,M Nishio,M Imoto,E Tashiro,N Hironiwa,M Kitagawa,Y Futamura,S Suzuki,M Nishio,M Imoto,E Tashiro,N Hironiwa,M Kitagawa,Y Futamura,S Suzuki,M Nishio,M Imoto,

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Trierixin, a Novel Inhibitor of ER Stress-induced XBP1 Activation from Streptomyces sp. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: The Journal of antibiotics

VOLUME: 60

Page Numbers: 547-53

Journal Abbreviation: J. Antibiot.

ISSN: 0021-8820

DAY: 5

MONTH: Sep

YEAR: 2007

Trierixin, a Novel Inhibitor of ER Stress-induced XBP1 Activation from Streptomyces sp. Information

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LANGUAGE: eng

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Grant and Affiliation Information for Trierixin, a Novel Inhibitor of ER Stress-induced XBP1 Activation from Streptomyces sp.

AFFILIATION: Department of Bioscience and Informatics, Faculty of Science and Technology, Keio University.

Country: Japan

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MEDLINETA: J Antibiot (Tokyo)

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