Trichomonas vaginalis: Reactive oxygen species mediates caspase-3 dependent apoptosis of human neutrophils.

Trichomonas vaginalis: Reactive oxygen species mediates caspase-3 dependent apoptosis of human neutrophils. Research Abstract Details 

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Trichomonas vaginalis: Reactive oxygen species mediates caspase-3 dependent apoptosis of human neutrophils. Abstract Text:

Hyun-Ouk Song,Myeong-Heon Shin,Myoung-Hee Ahn,Duk-Young Min,Yong-Seok Kim,Jae-Sook Ryu,

There are many neutrophils in the vaginal discharge from women infected with Trichomonas vaginalis. The aim of our study was to determine whether human neutrophil apoptosis may be regulated by reactive oxygen species (ROS) in response to trichomonads infection. Incubation of human neutrophils with live trichomonads caused marked receptor shedding of CD16, decrease of mitochondrial membrane potential (MMP) and caspase-3 activation in human neutrophils. These proapoptotic effects of T. vaginalis on neutrophils were inhibited by pretreatment of neutrophils with an inhibitor of NADPH oxidase, diphenyleneiodonium chloride (DPI), suggesting an important role of intracellular ROS accumulation in T. vaginalis-triggered apoptosis. Indeed, large amounts of ROS levels were detected in neutrophils incubated with live trichomonads, and were also effectively inhibited by DPI. However, pan-caspase inhibitor z-VAD-fmk or caspase-3 inhibitor z-DEVD-fmk did not affect T. vaginalis-induced ROS generation in neutrophils. These results suggest that ROS-dependent caspase-3 activation plays an important role in apoptosis of human neutrophils induced by T. vaginalis.

Trichomonas vaginalis: Reactive oxygen species mediates caspase-3 dependent apoptosis of human neutrophils. Publishing Authors By Initials

HO Song,MH Shin,MH Ahn,DY Min,YS Kim,JS Ryu,

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Trichomonas vaginalis: Reactive oxygen species mediates caspase-3 dependent apoptosis of human neutrophils. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Experimental parasitology

VOLUME: 118

Page Numbers: 59-65

Journal Abbreviation: Exp. Parasitol.

ISSN: 0014-4894

DAY: 13

MONTH: 07

YEAR: 2007

Trichomonas vaginalis: Reactive oxygen species mediates caspase-3 dependent apoptosis of human neutrophils. Information

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LANGUAGE: eng

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AFFILIATION: Department of Parasitology, Brain Korea 21, Hanyang University College of Medicine, 17 Haengdang-dong, Seongdong-gu, Seoul 133-791, Republic of Korea.

Country: United States

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MEDLINETA: Exp Parasitol

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