Trends in anti-bacterial resistance among Streptococcus pneumoniae isolated in the USA, 2000-2003: PROTEKT US years 1-3.

Trends in anti-bacterial resistance among Streptococcus pneumoniae isolated in the USA, 2000-2003: PROTEKT US years 1-3. Research Abstract Details 

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Trends in anti-bacterial resistance among Streptococcus pneumoniae isolated in the USA, 2000-2003: PROTEKT US years 1-3. Abstract Text:

Stephen G Jenkins,David J Farrell,Manish Patel,Bruce S Lavin,

OBJECTIVES: To determine geographic and temporal trends in anti-bacterial resistance among Streptococcus pneumoniae isolated from patients with respiratory tract infections as part of the PROTEKT US surveillance study (2000-2003). METHODS: From 2000 to 2003, 31 001 isolates of S. pneumoniae were collected. Anti-bacterial minimum inhibitory concentrations were determined at a central laboratory using the CLSI broth microdilution method. Macrolide resistance genotypes were determined by PCR. RESULTS: Overall, 29.4, 22.5, 0.9, and 0.02% of S. pneumoniae isolates were resistant to erythromycin, penicillin, levofloxacin, and telithromycin, respectively, with considerable regional variability. Multidrug resistance was stable at approx. 31%. Among macrolide-resistant isolates, mef(A) was the most prevalent resistance gene identified; however, the percentage of isolates with this gene decreased from 68.8% (2000) to 63.9% (2003), while the prevalence of isolates containing both the erm(B) and mef(A) genes increased (2000, 9.7%; 2003, 16.4%). Over 90% of these erm(B)+mef(A)-positive isolates were also resistant to penicillin, tetracycline, or trimethoprim-sulfamethoxazole, while 98.6% were susceptible to levofloxacin and 99.1% were susceptible to telithromycin. CONCLUSIONS: Penicillin and erythromycin resistance among isolates of S. pneumoniae from the U.S.A. remained high over the 3 years of the study. Telithromycin demonstrated potent in vitro activity against pneumococcal strains.

Trends in anti-bacterial resistance among Streptococcus pneumoniae isolated in the USA, 2000-2003: PROTEKT US years 1-3. Publishing Authors By Initials

SG Jenkins,DJ Farrell,M Patel,BS Lavin,

For similar geographic locations: americas: north america: united states research abstracts see: geographic locations: americas: north america: united states research

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Trends in anti-bacterial resistance among Streptococcus pneumoniae isolated in the USA, 2000-2003: PROTEKT US years 1-3. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: The Journal of infection

VOLUME: 51

Page Numbers: 355-63

Journal Abbreviation: J. Infect.

ISSN: 1532-2742

DAY: 13

MONTH: 06

YEAR: 2005

Trends in anti-bacterial resistance among Streptococcus pneumoniae isolated in the USA, 2000-2003: PROTEKT US years 1-3. Information

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LANGUAGE: eng

NlmUniqueID: 7908424

Trends in anti-bacterial resistance among Streptococcus pneumoniae isolated in the USA, 2000-2003: PROTEKT US years 1-3. Keywords Mesh Terms:

KEYWORDS: United States

MESH TERMS: genetics

Chemical & Substance for Abstract: Trends in anti-bacterial resistance among Streptococcus pneumoniae isolated in the USA, 2000-2003: PROTEKT US years 1-3. Information

Substance Name: ErmA protein, Bacteria

Registry Number: EC 2.1.1.48

Grant and Affiliation Information for Trends in anti-bacterial resistance among Streptococcus pneumoniae isolated in the USA, 2000-2003: PROTEKT US years 1-3.

AFFILIATION: Clinical Microbiology Laboratories, Department of Pathology, Mount Sinai School of Medicine, Mount Sinai Medical Center, New York, NY 10029-6574, USA. stephen.jenkins@mountsinai.org

Country: England

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MEDLINETA: J Infect

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