Trend of Drug-Resistant HIV Type 1 Emergence among Therapy-Naive Patients in Nagoya, Japan: An 8-Year Surveillance from 1999 to 2006.

Trend of Drug-Resistant HIV Type 1 Emergence among Therapy-Naive Patients in Nagoya, Japan: An 8-Year Surveillance from 1999 to 2006. Research Abstract Details 

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Trend of Drug-Resistant HIV Type 1 Emergence among Therapy-Naive Patients in Nagoya, Japan: An 8-Year Surveillance from 1999 to 2006. Abstract Text:

Shiro Ibe,Junko Hattori,Seiichiro Fujisaki,Urara Shigemi,Saeko Fujisaki,Kayoko Shimizu,Kazuyo Nakamura,Takejiro Kazumi,Yoshiyuki Yokomaku,Naoto Mamiya,Motohiro Hamaguchi,Tsuguhiro Kaneda,Shiro Ibe,Junko Hattori,Seiichiro Fujisaki,Urara Shigemi,Saeko Fujisaki,Kayoko Shimizu,Kazuyo Nakamura,Takejiro Kazumi,Yoshiyuki Yokomaku,Naoto Mamiya,Motohiro Hamaguchi,Tsuguhiro Kaneda,

We studied the emergence of drug-resistant human immunodeficiency virus type 1 (HIV-1) with major amino acid mutations in 402 therapy-naive patients at Nagoya Medical Center, Japan, between 1999 and 2006. The mean prevalence of drug-resistant HIV-1 was 6.7% (range, 2.3-10.0%; n = 27). HIV-1 variants with protease inhibitor (PI)-resistant mutations alone were most frequently found (3.5%, n = 14), followed by those with nonnucleoside reverse transcriptase inhibitor (NNRTI)-resistant mutations alone (1.7%, n = 7). Variants with nucleoside reverse transcriptase inhibitor (NRTI)-resistant mutations alone were sporadically found (1.0%, n = 4). A variant possessing both NRTI- and PI-resistant mutations was detected in one patient (0.2%) and a variant possessing both NNRTI- and PI-resistant mutations was identified in another patient (0.2%). In addition, another 17 variants (4.2%, n = 17) with only 215-revertant mutations (T215C/D/G/L/S) that can easily reconvert to the nucleoside analogue-associated mutation of T215Y/F were found. The 402 viruses were phylogenetically analyzed, revealing three independent clusters comprising PI-resistant variants with the M46I or L90M mutation, NNRTI-resistant variants with the K103N mutation, and 215-revertant variants. The PI-resistant and 215-revertant strains have been spreading since 2000, and the NNRTI-resistant strain has started spreading since 2003. The nature of the epidemic and information for successfully blocking the spread of drug-resistant HIV-1 were clarified in this study.

Trend of Drug-Resistant HIV Type 1 Emergence among Therapy-Naive Patients in Nagoya, Japan: An 8-Year Surveillance from 1999 to 2006. Publishing Authors By Initials

S Ibe,J Hattori,S Fujisaki,U Shigemi,S Fujisaki,K Shimizu,K Nakamura,T Kazumi,Y Yokomaku,N Mamiya,M Hamaguchi,T Kaneda,S Ibe,J Hattori,S Fujisaki,U Shigemi,S Fujisaki,K Shimizu,K Nakamura,T Kazumi,Y Yokomaku,N Mamiya,M Hamaguchi,T Kaneda,

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Trend of Drug-Resistant HIV Type 1 Emergence among Therapy-Naive Patients in Nagoya, Japan: An 8-Year Surveillance from 1999 to 2006. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: AIDS research and human retroviruses

VOLUME: 24

Page Numbers: 7-14

Journal Abbreviation: AIDS Res. Hum. Retroviruses

ISSN: 0889-2229

DAY: 15

MONTH: Jan

YEAR: 2008

Trend of Drug-Resistant HIV Type 1 Emergence among Therapy-Naive Patients in Nagoya, Japan: An 8-Year Surveillance from 1999 to 2006. Information

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LANGUAGE: eng

NlmUniqueID: 8709376

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AFFILIATION: Clinical Research Center, National Hospital Organization Nagoya Medical Center (Tokai Area Central Hospital for AIDS Treatment and Research), Nagoya, Aichi 460-0001, Japan.

Country: United States

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MEDLINETA: AIDS Res Hum Retroviruses

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