Treatment with amisulpride and olanzapine improve neuropsychological function in schizophrenia.

Treatment with amisulpride and olanzapine improve neuropsychological function in schizophrenia. Research Abstract Details 

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Treatment with amisulpride and olanzapine improve neuropsychological function in schizophrenia. Abstract Text:

Ann M Mortimer,Eileen Joyce,Krishnapillai Balasubramaniam,Prasoon C Choudhary,Packeeruther T Saleem, ,Ann M Mortimer,Eileen Joyce,Krishnapillai Balasubramaniam,Prasoon C Choudhary,Packeeruther T Saleem, ,

OBJECTIVES: Although antipsychotic drugs control acute psychotic manifestations of schizophrenia, improving cognitive symptoms is also important for long-term prognosis. METHODS: Three hundred and seventy-seven adult patients with acute psychosis were randomised to either amisulpride (200-800 mg/d) or olanzapine (5-20 mg/d) for 6 months. Neuropsychological performance was assessed at inclusion and after 6 months in a subgroup of 26 subjects (11 treated with amisulpride and 15 with olanzapine) using the Auditory Verbal Learning Test (AVLT), the Trail Making Test (TMT) and the Controlled Oral Word Association Test (COWAT). RESULTS: The improvement in BPRS score was similar in both treatment groups. No significant differences in test performance between groups were observed at inclusion. After 6 months, AVLT scores increased by 8.7 points in the amisulpride group and by 2.3 points in the olanzapine group (p = 0.049). Completion speed in the TMT increased by 17.4 s (amisulpride) and 15.4 s (olanzapine) for Part A and by 39.8 and 48.8 s, respectively for Part B. Performance in the COWAT improved little in both groups. CONCLUSIONS: Both amisulpride and olanzapine produce sustained improvement in certain measures of neuropsychological performance in patients with schizophrenia; a significant improvement in score on the AVLT was observed only with amisulpride.

Treatment with amisulpride and olanzapine improve neuropsychological function in schizophrenia. Publishing Authors By Initials

AM Mortimer,E Joyce,K Balasubramaniam,PC Choudhary,PT Saleem, ,AM Mortimer,E Joyce,K Balasubramaniam,PC Choudhary,PT Saleem, ,

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Treatment with amisulpride and olanzapine improve neuropsychological function in schizophrenia. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Human psychopharmacology

VOLUME: 22

Page Numbers: 445-54

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ISSN: 0885-6222

DAY: 1

MONTH: Oct

YEAR: 2007

Treatment with amisulpride and olanzapine improve neuropsychological function in schizophrenia. Information

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LANGUAGE: eng

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AFFILIATION: University of Hull, Hull, UK. A.M.Mortimer@hull.ac.uk

Country: England

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MEDLINETA: Hum Psychopharmacol

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