[Treatment outcome and prognosis of 112 patients with nasal and nasopharyngeal peripheral T cell lymphomas]

[Treatment outcome and prognosis of 112 patients with nasal and nasopharyngeal peripheral T cell lymphomas] Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

[Treatment outcome and prognosis of 112 patients with nasal and nasopharyngeal peripheral T cell lymphomas] Abstract Text:

Yu-jing Zhang,Zhong-min Ren,Qiu-liang Wu,Zhen-yu He,Yan Huang,Yun-fei Xia,Tong-yu Lin,Nian-ji Cui,

OBJECTIVE: To retrospectively analyze the treatment outcomes and prognostic factors of nasal and nasopharyngeal peripheral T cell lymphomas (PTCL) patients. METHODS: One hundred and twelve patients with pathologically confirmed nasal and nasopharyngeal PTCL were included, among which 39 were CD56(+) NK/T cell lymphomas. The median pre-treatment disease course was 4 months. 84 were males and 28 females median age was 46 years. The tumors mainly involved nasal cavity (88 cases) and/or nasopharynx (50 cases) and adjacent structures, and 83 cases with extra-cavity diseases. 91.1% of the patients had Ann Arbor I(E)/II(E) diseases. The International Prognostic Indices (IPI) were less than 2 scores in 78.8% of the patients. Seventy two patients received combined chemo-radiotherapy, 32 chemotherapy only, 3 radiotherapy only and 5 no any treatment. RESULTS: Median follow-up duration was 42 months. Chemotherapy achieved a complete remission (CR) rate of 34.4% for initial treatment, and of 65.1% after primary treatment. The local tumor controlled rate was 50.5%, and the median time to tumor progression (TTP) was 11 months. There were evidences of systemic relapse in more than 30% of the patients. The extra-cavity tumors usually had a shorter TTP (r(s) = -0.191, P = 0.024). The progress-free survival and overall survival rates were 38.8% and 52.4% at 3 years, and 34.9% and 44.8% at 5 years respectively. Univariate analysis showed that favorable prognostic factors for survival were pre-treatment course > 3 months, earlier clinical stage, non NK/T lymphoma, no skin involvement, lower IPI, CR after initial chemotherapy, radiotherapy, CR after primary treatment and local tumor controlled. Multivariate analysis showed that, pre-treatment course > 3 months (P = 0.011), non NK/T lymphoma (P = 0.007), CR after initial chemotherapy (P = 0.008) and radiotherapy (P = 0.000) were favorable prognostic factors for survival. CONCLUSIONS: Although most nasal and nasopharyngeal peripheral T-cell lymphomas were diagnosed at early stage diseases, some of them were highly aggressive with poor prognosis, particularly CD56(+) NK/T cell lymphomas. Combination chemo/radiotherapy, though remained principal treatments, more effective therapeutic modalities are expected.

[Treatment outcome and prognosis of 112 patients with nasal and nasopharyngeal peripheral T cell lymphomas] Publishing Authors By Initials

YJ Zhang,ZM Ren,QL Wu,ZY He,Y Huang,YF Xia,TY Lin,NJ Cui,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

[Treatment outcome and prognosis of 112 patients with nasal and nasopharyngeal peripheral T cell lymphomas] Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Zhonghua xue ye xue za zhi = Zhonghua xueyexue zaz

VOLUME: 27

Page Numbers: 217-21

Journal Abbreviation:

ISSN: 0253-2727

DAY: 31

MONTH: Apr

YEAR: 2006

[Treatment outcome and prognosis of 112 patients with nasal and nasopharyngeal peripheral T cell lymphomas] Information

Number of References:

LANGUAGE: chi

NlmUniqueID: 8212398

[Treatment outcome and prognosis of 112 patients with nasal and nasopharyngeal peripheral T cell lymphomas] Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: [Treatment outcome and prognosis of 112 patients with nasal and nasopharyngeal peripheral T cell lymphomas] Information

Substance Name:

Registry Number:

Grant and Affiliation Information for [Treatment outcome and prognosis of 112 patients with nasal and nasopharyngeal peripheral T cell lymphomas]

AFFILIATION: Department of Radiation Oncology, State Key Laboratory of Oncology in Southern China, Cancer Center, Sun Yat-sen University, Guangzhou 510060, China.

Country: China

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Zhonghua Xue Ye Xue Za Zhi

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Treatment outcome and prognosis of 112 patients with nasal and nasopharyngeal peripheral T cell lymphomas Related Publications

• Combining gene expression QTL mapping and phenotypic spectrum analysis to uncover gene regulatory relationships.
• Effects of temperature and salt concentration on the structural stability of human lymphotactin: insights from molecular simulations.
• Localization of NKCC1 in the cochlea and morphology of the cochlea in NKCC1-knockout mice.
• New Triterpenoids Isolated from the Root Bark of Ulmus pumila L.
• New wiggler beamlines at BSRF.
• Unique molecular signatures of glycerophospholipid species in different rat tissues analyzed by tandem mass spectrometry.
• [A case of angiosarcoma developed from liver hamartomas]
• [Analysis of MYH7, MYBPC3 and TNNT2 gene mutations in 10 Chinese pedigrees with familial hypertrophic cardiomyopathy and the correlation between genotype and phenotype]
• [Association between serum cardiac troponin I and myocardial remodeling in patients with chronic heart failure]
• [Association of age-related hearing loss with mice which expressed only one copy of gene encoding NKCC1 co-transporter]
• [Changes in pro-inflammatory cytokines and media and peptide hormones during multiple organ dysfunction syndrome following acute abdominal diseases]
• [Clinical features and prognosis of nasal type NK/T cell lymphoma]
• [Clinical study on preventive effect of fuzheng quxie granule on respiratory viral infection]
• [Clinical value of barium swallow in observing esophageal tumor regression during radiotherapy]
• [Comparison of heterotopic ossification between femoral head reconstruction and total hip arthroplasty in patients with ischemic necrosis of femoral head]
• [Degradation of endocrine disruptor atrazine in drinking water by UV radiation]
• [Developments of chronobiology abroad]
• [Discussion on the usage of terminology of some parasites and parasitic diseases]
• [Effects of cordyceps sinensis alcohol extractive on serum interferon-gamma level and splenic T lymphocyte subset in mice with viral myocarditis]
• [Gene rearrangement studies in Hashimoto's thyroiditis and primary lymphoma of thyroid]
• [Investigation on accidents happened during 1966-2003 in one petrochemical enterprise]
• [Kanamycin induced ototoxicity in three kinds of mouse strains and its effects on the expression of na-K-2Cl co-transporter-1 in stria vascularis]
• [Kinetic study on collagen mineralization by ultraviolet absorption spectra]
• [Newcastle disease virus heredity mutation and correlation of HN and F gene]
• [Pharmacokinetic study of ketoprofen in rat by blood microdialysis technique]
• [Role of eukaryotic initiation factor-4E (eIF-4E) in regulation of expression of NF-kappaB and its subsequent influence on transcription and activity of heparanase in human colon adenocarcinoma cell line]
• [Study of the nucleation sites in collagen mineralization]
• [Tissue engineered bone regeneration of periosteal cells using recombinant human bone morphogenetic protein 2 induce]
• [Treatment outcome and prognosis of 112 patients with nasal and nasopharyngeal peripheral T cell lymphomas]
• [Visual and histologic analysis of laparoscopic diagnosis of endometriosis]