Treatment of post-myocardial infarction depressive disorder.

Treatment of post-myocardial infarction depressive disorder. Research Abstract Details 

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Treatment of post-myocardial infarction depressive disorder. Abstract Text:

Both major and minor depressive disorder post-myocardial infarction (MI) are associated with an increased risk of all-cause mortality, cardiac mortality and new cardiovascular events. Post-MI depressive disorder predicts slow recovery and poor quality of life. This review attends to post-MI depressive disorder, its underlying mechanisms and options for and effects of treatment. Evidence has been found for several mechanisms to be involved in the pathophysiology, including hypothalamus-pituitary-adrenal axis activity, immune activity, polyunsaturated fatty acids, serotonin, platelet activation, type D personality and negative health behavior. Five leading randomized controlled trials are discussed, showing safety and efficacy of antidepressive treatment in post-MI patients. Effects on cardiac outcome remain unclear.

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Treatment of post-myocardial infarction depressive disorder. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Expert review of neurotherapeutics

VOLUME: 8

Page Numbers: 1115-23

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ISSN: 1744-8360

DAY: 1

MONTH: Jul

YEAR: 2008

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LANGUAGE: eng

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Grant and Affiliation Information for Treatment of post-myocardial infarction depressive disorder.

AFFILIATION: Department of Psychiatry, Academic Medical Center Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands. a.m.g.kuyper@chello.nl

Country: England

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MEDLINETA: Expert Rev Neurother

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