Treatment of metastatic gestational trophoblastic neoplasia.

Treatment of metastatic gestational trophoblastic neoplasia. Research Abstract Details 

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Treatment of metastatic gestational trophoblastic neoplasia. Abstract Text:

N E van Trommel,L F A G Massuger,P N Span,F C G J Sweep,C M G Thomas,

Treatment of persistent gestational trophoblastic neoplasia (GTN) has been one of the success stories of modern day chemotherapy; however, occasional patients with metastatic disease still die. A potential difficulty in assessing published studies is that patient groups can be selected for treatment differently according to how risk categories are defined. The involvement of a specialist team from the outset is essential. Patients with low-risk metastatic GTN are treated successfully with single-agent chemotherapy using methotrexate or dactinomycin. Patients with high-risk metastatic disease receive combination chemotherapy regimens from the start. Worldwide experience has been accrued by use of regimens devised and tested by large centres. The high response rate and good long-term survival, as well as the tolerable acute and cumulative toxic effects, associated with use of etoposide, methotrexate and dactinomycin, alternating with cyclophosphamide and vincristine, make this protocol, or one of its variants, the current initial treatment of choice for patients. In view of the success of these regimens difficulty would be encountered in mounting a worthwhile randomised controlled trial; however, further well-designed studies are needed of novel approaches in very-high-risk and multiresistant disease.

Treatment of metastatic gestational trophoblastic neoplasia. Publishing Authors By Initials

NE van Trommel,LF Massuger,PN Span,FC Sweep,CM Thomas,

For similar heterocyclic compounds: alkaloids: indole alkaloids: secologanin tryptamine alkaloids: vinca alkaloids: vincristine research abstracts see: heterocyclic compounds: alkaloids: indole alkaloids: secologanin tryptamine alkaloids: vinca alkaloids: vincristine research

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Treatment of metastatic gestational trophoblastic neoplasia. Journal Published:

PUBLICATION TYPE: Review

Journal: The lancet oncology

VOLUME: 8

Page Numbers: 715-24

Journal Abbreviation: Lancet Oncol.

ISSN: 1470-2045

DAY: 20

MONTH: Aug

YEAR: 2007

Treatment of metastatic gestational trophoblastic neoplasia. Information

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LANGUAGE: eng

NlmUniqueID: 100957246

Treatment of metastatic gestational trophoblastic neoplasia. Keywords Mesh Terms:

KEYWORDS: Vincristine

MESH TERMS: therapeutic use

Chemical & Substance for Abstract: Treatment of metastatic gestational trophoblastic neoplasia. Information

Substance Name: Methotrexate

Registry Number: 59-05-2

Grant and Affiliation Information for Treatment of metastatic gestational trophoblastic neoplasia.

AFFILIATION: Cancer Research Centre, Weston Park Hospital, Sheffield, UK.

Country: England

AGENCY:

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MEDLINETA: Lancet Oncol

REFSOURCE: Lancet Oncol. 2007 Oct;8(10):866-7

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