Treatment of keratin intermediate filaments with sulfur mustard analogs.

Treatment of keratin intermediate filaments with sulfur mustard analogs. Research Abstract Details 

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Treatment of keratin intermediate filaments with sulfur mustard analogs. Abstract Text:

John F Hess,Paul G FitzGerald,

Sulfur mustard (SM) is an alkylating agent with a history of use as a chemical weapon. The chemical reactivity of sulfur mustard toward both proteins and nucleic acids coupled with the hours long delay between exposure and appearance of blisters has prevented the determination of the mechanism of blister formation. We have treated assembled keratin intermediate filaments with analogs of sulfur mustard to simulate exposure to SM. We find that treatment of intact filaments with chloroethyl ethyl sulfide (CEES) or mechlorethamine (MEC) produces aggregates of keratin filaments with little native appearing structure. Treatment of a mix of epidermal keratins 1/10 (keratin pair 1 and 10) and keratins 5/14 with a sulfhydryl-specific modification reagent also results in filament abnormalities. Our results are consistent with the hypothesis that modification of keratins by SM would result in keratin filament destruction, leading to lysis of epidermal basal cells and skin blistering.

Treatment of keratin intermediate filaments with sulfur mustard analogs. Publishing Authors By Initials

JF Hess,PG FitzGerald,

For similar organic chemicals: hydrocarbons: hydrocarbons, halogenated: mustard compounds: mustard gas research abstracts see: organic chemicals: hydrocarbons: hydrocarbons, halogenated: mustard compounds: mustard gas research

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MEDLINE DATE:

Treatment of keratin intermediate filaments with sulfur mustard analogs. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Biochemical and biophysical research communication

VOLUME: 359

Page Numbers: 616-21

Journal Abbreviation: Biochem. Biophys. Res. Commun.

ISSN: 0006-291X

DAY: 29

MONTH: 05

YEAR: 2007

Treatment of keratin intermediate filaments with sulfur mustard analogs. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 372516

Treatment of keratin intermediate filaments with sulfur mustard analogs. Keywords Mesh Terms:

KEYWORDS: Mustard Gas

MESH TERMS: pharmacology

Chemical & Substance for Abstract: Treatment of keratin intermediate filaments with sulfur mustard analogs. Information

Substance Name: Keratins

Registry Number: 68238-35-7

Grant and Affiliation Information for Treatment of keratin intermediate filaments with sulfur mustard analogs.

AFFILIATION: Department of Cell Biology and Human Anatomy, School of Medicine, University of California, 1 Shields Ave., Davis, CA 95616-8643, USA. jfhess@ucdavis.edu

Country: United States

AGENCY: United States NEI

GRANT: R01 EY08747

ACRONYM: EY

MEDLINETA: Biochem Biophys Res Commun

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