Treatment of hypopituitarism with recombinant somatropin for 1 year.

Treatment of hypopituitarism with recombinant somatropin for 1 year. Research Abstract Details 

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Treatment of hypopituitarism with recombinant somatropin for 1 year. Abstract Text:

K Takano,K Shizume,I Hibi,A Okuno,K Hanyu,S Suwa,H Nakajima,T Kondo,K Kato,N Iwatani,

Twenty-five hypopituitary patients were treated with recombinant somatropin for 1 year at a dosage of 0.5 IU/kg/week. In previously untreated patients (n = 16), heights increased by between 4.5 and 10.2 cm, with a mean height velocity of 7.7 +/- 1.8 cm/year (mean +/- SD). In previously treated patients (n = 9), heights increased by between 3.9 and 7.6 cm, with a mean height velocity of 5.8 +/- 1.0 cm/year, similar to that observed during previous treatment with pituitary GH. Anti-GH antibodies were observed in two patients at a low titre. The antibodies disappeared in one patient during the treatment. These data indicate that recombinant somatropin has a growth promoting effect and low immunogenicity.

Treatment of hypopituitarism with recombinant somatropin for 1 year. Publishing Authors By Initials

K Takano,K Shizume,I Hibi,A Okuno,K Hanyu,S Suwa,H Nakajima,T Kondo,K Kato,N Iwatani,

For similar proteins: recombinant proteins research abstracts see: proteins: recombinant proteins research

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Treatment of hypopituitarism with recombinant somatropin for 1 year. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Acta paediatrica Scandinavica. Supplement

VOLUME: 347

Page Numbers: 169-75

Journal Abbreviation:

ISSN: 0300-8843

DAY: 20

MONTH: 02

YEAR: 1988

Treatment of hypopituitarism with recombinant somatropin for 1 year. Information

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LANGUAGE: eng

NlmUniqueID: 173166

Treatment of hypopituitarism with recombinant somatropin for 1 year. Keywords Mesh Terms:

KEYWORDS: Recombinant Proteins

MESH TERMS: drug therapy

Chemical & Substance for Abstract: Treatment of hypopituitarism with recombinant somatropin for 1 year. Information

Substance Name: Growth Hormone

Registry Number: 9002-72-6

Grant and Affiliation Information for Treatment of hypopituitarism with recombinant somatropin for 1 year.

AFFILIATION: Committee for Treatment of Pituitary Dwarfism, Foundation for Growth Science in Japan.

Country: SWEDEN

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MEDLINETA: Acta Paediatr Scand Suppl

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