Treatment of coumarin-induced skin necrosis with a monoclonal antibody purified protein C concentrate.

Treatment of coumarin-induced skin necrosis with a monoclonal antibody purified protein C concentrate. Research Abstract Details 

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Treatment of coumarin-induced skin necrosis with a monoclonal antibody purified protein C concentrate. Abstract Text:

BACKGROUND AND DESIGN--Protein C is a vitamin K-dependent plasma protein that is converted to the serine protease activated protein C by the thrombin-thrombomodulin complex. Activated protein C functions as a natural anticoagulant by inactivating the cofactors of the coagulation cascade, factors Va and VIIIa. Coumarin (warfarin)-induced skin necrosis is thought to be due to a rapid elimination of protein C relative to other vitamin K-dependent factors during the initial phase of oral anticoagulation. We have used a highly purified protein C concentrate to treat a patient with acquired protein C deficiency who developed skin necrosis during the initial phase of oral anticoagulant therapy. OBSERVATIONS AND CONCLUSIONS--During protein C concentrate therapy, no further skin lesions appeared, and the healing process of necrotic areas was facilitated. Replacement therapy with protein C concentrate appears to be safe and effective as an adjunctive treatment for coumarin-induced skin necrosis.

Treatment of coumarin-induced skin necrosis with a monoclonal antibody purified protein C concentrate. Publishing Authors By Initials

For similar integumentary system: skin research abstracts see: integumentary system: skin research

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Treatment of coumarin-induced skin necrosis with a monoclonal antibody purified protein C concentrate. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Archives of dermatology

VOLUME: 129

Page Numbers: 753-6

Journal Abbreviation: Arch Dermatol

ISSN: 0003-987X

DAY: 17

MONTH: Jun

YEAR: 1993

Treatment of coumarin-induced skin necrosis with a monoclonal antibody purified protein C concentrate. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 372433

Treatment of coumarin-induced skin necrosis with a monoclonal antibody purified protein C concentrate. Keywords Mesh Terms:

KEYWORDS: Skin

MESH TERMS: pathology

Chemical & Substance for Abstract: Treatment of coumarin-induced skin necrosis with a monoclonal antibody purified protein C concentrate. Information

Substance Name: coumarin

Registry Number: 91-64-5

Grant and Affiliation Information for Treatment of coumarin-induced skin necrosis with a monoclonal antibody purified protein C concentrate.

AFFILIATION: Medizinische Klinik Innenstadt, University of Munich, Germany.

Country: UNITED STATES

AGENCY: United States NHLBI

GRANT: P01 HL 33014

ACRONYM: HL

MEDLINETA: Arch Dermatol

REFSOURCE: Arch Dermatol. 1993 Jun;129(6):766-8

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