Treatment of adult neural progenitor cells prior to transplantation affects graft survival and integration in a neonatal and adult rat model of selective retinal ganglion cell depletion.

Treatment of adult neural progenitor cells prior to transplantation affects graft survival and integration in a neonatal and adult rat model of selective retinal ganglion cell depletion. Research Abstract Details 

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Treatment of adult neural progenitor cells prior to transplantation affects graft survival and integration in a neonatal and adult rat model of selective retinal ganglion cell depletion. Abstract Text:

Carla B Mellough,Qi Cui,Alan R Harvey,

PURPOSE: We tested whether microenvironmental changes surrounding apoptotic neural degeneration, cellular pre-treatment and timing of transplant can influence the survival and differentiation of transplanted cells. This was done by transplanting adult hippocampal precursor cells (AHPCs) into normal and retinal ganglion cell (RGC) depleted rat retinae. METHODS: Apoptotic RGC death was induced in neonates by removal of the contralateral superior colliculus (SC) and in adults by unilateral optic nerve transection, with or without a peripheral nerve (PN) graft. AHPCs were transplanted 24 h after SC ablation, or 5, 7 or 14 days following optic nerve (ON) transection. Hosts received untreated grafts, or grafts treated by co-culture with embryonic retinal explants or the neuropeptide somatostatin. RESULTS: AHPCs integrated within all neonatal and 65% of adult retinae. Greater numbers of AHPCs were observed within the ganglion cell layer (GCL) in SC lesioned hosts. Explant co-culture induced proliferation of grafted AHPCs within host retinae. Somatostatin-treatment resulted in reduced overall engraftment but increased integration within the GCL. In lesioned adults, greatest GCL engraftment was observed following 7 or 14 day grafts. Some AHPCs in the inner retina expressed neuronal antigens and extended processes into the ON. CONCLUSIONS: These data indicate that various factors can influence the behaviour of grafted cells and work towards encouraging the functional restoration of retinal circuitry.

Treatment of adult neural progenitor cells prior to transplantation affects graft survival and integration in a neonatal and adult rat model of selective retinal ganglion cell depletion. Publishing Authors By Initials

CB Mellough,Q Cui,AR Harvey,

For similar cells: stem cells research abstracts see: cells: stem cells research

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Treatment of adult neural progenitor cells prior to transplantation affects graft survival and integration in a neonatal and adult rat model of selective retinal ganglion cell depletion. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Restorative neurology and neuroscience

VOLUME: 25

Page Numbers: 177-90

Journal Abbreviation: Restor. Neurol. Neurosci.

ISSN: 0922-6028

DAY: 19

MONTH: 11

YEAR: 2007

Treatment of adult neural progenitor cells prior to transplantation affects graft survival and integration in a neonatal and adult rat model of selective retinal ganglion cell depletion. Information

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LANGUAGE: eng

NlmUniqueID: 9005499

Treatment of adult neural progenitor cells prior to transplantation affects graft survival and integration in a neonatal and adult rat model of selective retinal ganglion cell depletion. Keywords Mesh Terms:

KEYWORDS: Stem Cells

MESH TERMS: pathology

Chemical & Substance for Abstract: Treatment of adult neural progenitor cells prior to transplantation affects graft survival and integration in a neonatal and adult rat model of selective retinal ganglion cell depletion. Information

Substance Name: Somatostatin

Registry Number: 51110-01-1

Grant and Affiliation Information for Treatment of adult neural progenitor cells prior to transplantation affects graft survival and integration in a neonatal and adult rat model of selective retinal ganglion cell depletion.

AFFILIATION: School of Anatomy & Human Biology, The University of Western Australia, 35 Stirling Hwy, Crawley, Perth 6009, WA, Australia.

Country: Netherlands

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MEDLINETA: Restor Neurol Neurosci

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