Transthyretin and amyloid in the islets of langerhans in type-2 diabetes.

Transthyretin and amyloid in the islets of langerhans in type-2 diabetes. Research Abstract Details 

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Transthyretin and amyloid in the islets of langerhans in type-2 diabetes. Abstract Text:

Transthyretin (TTR) is a major amyloid fibril protein in certain systemic forms of amyloidosis. It is a plasma protein, mainly synthesized by the liver but expression occurs also at certain minor locations, including the endocrine cells in the islets of Langerhans. With the use of immunohistochemistry and in situ hybridization, we have studied the distribution of transthyretin-containing cells in islets of Langerhans in type-2 diabetic and nondiabetic individuals. TTR expression was particularly seen in alpha (glucagon) cells. Islets from type-2 diabetic patients had proportionally more transthyretin-reactive islet cells, including beta cells. A weak transthyretin immunoreaction in IAPP-derived amyloid occurred in some specimens. In seeding experiments in vitro, we found that TTR fibrils did not seed IAPP while IAPP fibrils seeded TTR. It is suggested that islet expression of transthyretin may be altered in type-2 diabetes.

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Transthyretin and amyloid in the islets of langerhans in type-2 diabetes. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Experimental diabetes research

VOLUME: 2008

Page Numbers: 429274

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ISSN: 1687-5303

DAY: 30

MONTH: 09

YEAR: 2008

Transthyretin and amyloid in the islets of langerhans in type-2 diabetes. Information

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LANGUAGE: eng

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Grant and Affiliation Information for Transthyretin and amyloid in the islets of langerhans in type-2 diabetes.

AFFILIATION: Department of Clinical and Experimental Medicine, Linköping University, 581 85 Linköping, Sweden.

Country: United States

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MEDLINETA: Exp Diabetes Res

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