Transport of mu-opioid receptor agonists and antagonist peptides across Caco-2 monolayer.

Transport of mu-opioid receptor agonists and antagonist peptides across Caco-2 monolayer. Research Abstract Details 

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Transport of mu-opioid receptor agonists and antagonist peptides across Caco-2 monolayer. Abstract Text:

Milk is the source of beta-casomorphins - biologically active peptides with opioid activity - which are suspected to play various roles in the human body. The local influence of exogenous opioid peptides on gastrointestinal functions has been widely reported. After passing the gut barrier, beta-casomorphins may affect the functions of immunological system, as well as dopaminergic, serotoninergic and GABA-ergic systems in brain, regulate the opioid receptor development and elicit behavioral effects. However, possibilities and mechanisms of the intestinal transport of beta-casomorphins in human body in vivo have not been reported so far. In our research, the transepithelial transport of mu-opioid receptor agonists - human beta-casomorphin-5 and 7(BCM5, BCM7) and antagonist - lactoferroxin A (LCF A) have been investigated using Caco-2 monolayer. In order to determine the pathway of investigated peptide transport across Caco-2 monolayer, two directions of the transport (apical to basolateral and basolateral to apical) have been studied. All investigated peptides were transported across the human intestinal cell line Caco-2 and the curves of cumulative amount of transported peptides in time were linear in each case. In addition, the hydrolysis of beta-casomorphins during 60min of experiment by dipeptidyl peptidase IV was observed. The data suggest the possibility of transport of opioid peptides derived from food across human intestinal mucosa.

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Transport of mu-opioid receptor agonists and antagonist peptides across Caco-2 monolayer. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Peptides

VOLUME: 29

Page Numbers: 1042-7

Journal Abbreviation: Peptides

ISSN: 0196-9781

DAY: 6

MONTH: 02

YEAR: 2008

Transport of mu-opioid receptor agonists and antagonist peptides across Caco-2 monolayer. Information

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LANGUAGE: eng

NlmUniqueID: 8008690

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Grant and Affiliation Information for Transport of mu-opioid receptor agonists and antagonist peptides across Caco-2 monolayer.

AFFILIATION: Chair of Biochemistry, Faculty of Biology, University of Warmia and Mazury, Oczapowskiego 1A, 10-19 Olsztyn, Poland.

Country: United States

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MEDLINETA: Peptides

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