Transplanted endothelial cells enhance orthotopic bone regeneration.

Transplanted endothelial cells enhance orthotopic bone regeneration. Research Abstract Details 

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Transplanted endothelial cells enhance orthotopic bone regeneration. Abstract Text:

D Kaigler,P H Krebsbach,Z Wang,E R West,K Horger,D J Mooney,

The aim of this study was to determine if endothelial cells could enhance bone marrow stromal-cell-mediated bone regeneration in an osseous defect. Using poly-lactide-co-glycolide scaffolds as cell carriers, we transplanted bone marrow stromal cells alone or with endothelial cells into 8.5-mm calvarial defects created in nude rats. Histological analyses of blood vessel and bone formation were performed, and microcomputed tomography (muCT) was used to assess mineralized bone matrix. Though the magnitude of the angiogenic response between groups was the same, muCT analysis revealed earlier mineralization of bone in the co-transplantation condition. Ultimately, there was a significant increase (40%) in bone formation in the co-transplantation group (33 +/- 2%), compared with the transplantation of bone marrow stromal cells alone (23 +/- 3%). Analysis of these data demonstrates that, in an orthotopic site, transplanted endothelial cells can influence the bone-regenerative capacity of bone marrow stromal cells.

Transplanted endothelial cells enhance orthotopic bone regeneration. Publishing Authors By Initials

D Kaigler,PH Krebsbach,Z Wang,ER West,K Horger,DJ Mooney,

For similar investigative techniques: clinical laboratory techniques: culture techniques: tissue engineering research abstracts see: investigative techniques: clinical laboratory techniques: culture techniques: tissue engineering research

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Transplanted endothelial cells enhance orthotopic bone regeneration. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Journal of dental research

VOLUME: 85

Page Numbers: 633-7

Journal Abbreviation: J. Dent. Res.

ISSN: 0022-0345

DAY: 3

MONTH: Jul

YEAR: 2006

Transplanted endothelial cells enhance orthotopic bone regeneration. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 354343

Transplanted endothelial cells enhance orthotopic bone regeneration. Keywords Mesh Terms:

KEYWORDS: Tissue Engineering

MESH TERMS: transplantation

Chemical & Substance for Abstract: Transplanted endothelial cells enhance orthotopic bone regeneration. Information

Substance Name: Lactic Acid

Registry Number: 50-21-5

Grant and Affiliation Information for Transplanted endothelial cells enhance orthotopic bone regeneration.

AFFILIATION: Dept. of Periodontics, University of Michigan, Ann Arbor, MI 48109, USA.

Country: United States

AGENCY: United States NIDCR

GRANT: R01-DE013835

ACRONYM: DE

MEDLINETA: J Dent Res

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