Transplantation of canine umbilical cord blood-derived mesenchymal stem cells in experimentally induced spinal cord injured dogs.

Transplantation of canine umbilical cord blood-derived mesenchymal stem cells in experimentally induced spinal cord injured dogs. Research Abstract Details 

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Transplantation of canine umbilical cord blood-derived mesenchymal stem cells in experimentally induced spinal cord injured dogs. Abstract Text:

Ji Hey Lim,Ye Eun Byeon,Hak Hyun Ryu,Yun Hyeok Jeong,Young Won Lee,Wan Hee Kim,Kyung Sun Kang,Oh Kyeong Kweon,Ji Hey Lim,Ye Eun Byeon,Hak Hyun Ryu,Yun Hyeok Jeong,Young Won Lee,Wan Hee Kim,Kyung Sun Kang,Oh Kyeong Kweon,

This study was to determine the effects of allogenic umbilical cord blood (UCB)-derived mesenchymal stem cells (MSCs) and recombinant methionyl human granulocyte colony-stimulating factor (rmhGCSF) on a canine spinal cord injury model after balloon compression at the first lumbar vertebra. Twenty-five adult mongrel dogs were assigned to five groups according to treatment after a spinal cord injury: no treatment (CN); saline treatment (CP); rmhGCSF treatment (G); UCB-MSCs treatment (UCB-MSC); co-treatment (UCBG). The UCBMSCs isolated from cord blood of canine fetuses were prepared as 10(6) cells/150 microl saline. The UCB-MSCs were directly injected into the injured site of the spinal cord and rmhGCSF was administered subcutaneously 1 week after the induction of spinal cord injury. The Olby score, magnetic resonance imaging, somatosensory evoked potentials and histopathological examinations were used to evaluate the functional recovery after transplantation. The Olby scores of all groups were zero at the 0-week evaluation. At 2 week after the transplantation, the Olby scores in the groups with the UCB-MSC and UCBG were significantly higher than in the CN and CP groups. However, there were no significant differences between the UCB-MSC and UCBG groups, and between the CN and CP groups. These comparisons remained stable at 4 and 8 week after transplantation. There was significant improvement in the nerve conduction velocity based on the somatosensory evoked potentials. In addition, a distinct structural consistency of the nerve cell bodies was noted in the lesion of the spinal cord of the UCB-MSC and UCBG groups. These results suggest that transplantation of the UCB-MSCs resulted in recovery of nerve function in dogs with a spinal cord injury and may be considered as a therapeutic modality for spinal cord injury.

Transplantation of canine umbilical cord blood-derived mesenchymal stem cells in experimentally induced spinal cord injured dogs. Publishing Authors By Initials

JH Lim,YE Byeon,HH Ryu,YH Jeong,YW Lee,WH Kim,KS Kang,OK Kweon,JH Lim,YE Byeon,HH Ryu,YH Jeong,YW Lee,WH Kim,KS Kang,OK Kweon,

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Transplantation of canine umbilical cord blood-derived mesenchymal stem cells in experimentally induced spinal cord injured dogs. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of veterinary science (Suw?n-si, Korea)

VOLUME: 8

Page Numbers: 275-82

Journal Abbreviation: J. Vet. Sci.

ISSN: 1229-845X

DAY: 7

MONTH: Sep

YEAR: 2007

Transplantation of canine umbilical cord blood-derived mesenchymal stem cells in experimentally induced spinal cord injured dogs. Information

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LANGUAGE: eng

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AFFILIATION: Department of Veterinary Surgery, College of Veterinary Medicine, Seoul National University, Seoul, Korea.

Country: Korea (South)

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MEDLINETA: J Vet Sci

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