Transplacental effects of ethylnitrosourea precursors ethylurea and sodium nitrite in hamsters.

Transplacental effects of ethylnitrosourea precursors ethylurea and sodium nitrite in hamsters. Research Abstract Details 

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Transplacental effects of ethylnitrosourea precursors ethylurea and sodium nitrite in hamsters. Abstract Text:

Four simultaneous dosages of the ethylnitrosourea precursors, ethylurea and sodium nitrite, were administered intragastrically to pregnant hamsters at 100 mg/kg and 50 mg/kg respectively, from the 12-15th days of pregnancy. The treatment induced multiple neurogenic tumors of the peripheral nervous system in the offspring. Female progeny developed a greater incidence and multiplicity of peripheral nervous system tumors with significantly shorter latencies than males, thus establishing evidence that the tumors were age and sex dependent. The tumors presented varied morphological patterns and upon transplantation, grew regularly, exhibiting their malignant nature. The possible influence of estrogenic hormones on the development and growth of peripheral nervous system tumors and comparative aspects of the relationship between prenatal and postnatal carcinogenesis with regard to the ensuing tumor spectra as a consequence of exposure to the same chemical agent, are discussed.

Transplacental effects of ethylnitrosourea precursors ethylurea and sodium nitrite in hamsters. Publishing Authors By Initials

For similar organic chemicals: urea research abstracts see: organic chemicals: urea research

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Transplacental effects of ethylnitrosourea precursors ethylurea and sodium nitrite in hamsters. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Zeitschrift für Krebsforschung und klinische Onkol

VOLUME: 85

Page Numbers: 201-7

Journal Abbreviation:

ISSN: 0084-5353

DAY: 19

MONTH: Mar

YEAR: 1976

Transplacental effects of ethylnitrosourea precursors ethylurea and sodium nitrite in hamsters. Information

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LANGUAGE: eng

NlmUniqueID: 1276653

Transplacental effects of ethylnitrosourea precursors ethylurea and sodium nitrite in hamsters. Keywords Mesh Terms:

KEYWORDS: Urea

MESH TERMS: analogs & derivatives

Chemical & Substance for Abstract: Transplacental effects of ethylnitrosourea precursors ethylurea and sodium nitrite in hamsters. Information

Substance Name: Ethylnitrosourea

Registry Number: 759-73-9

Grant and Affiliation Information for Transplacental effects of ethylnitrosourea precursors ethylurea and sodium nitrite in hamsters.

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Country: GERMANY, WEST

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MEDLINETA: Z Krebsforsch Klin Onkol Cance

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