Transneuronal tracing of neural pathways that regulate hindlimb muscle blood flow.

Transneuronal tracing of neural pathways that regulate hindlimb muscle blood flow. Research Abstract Details 

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Transneuronal tracing of neural pathways that regulate hindlimb muscle blood flow. Abstract Text:

T-K Lee,J H Lois,J H Troupe,T D Wilson,B J Yates,

Despite considerable interest in the neural mechanisms that regulate muscle blood flow, the descending pathways that control sympathetic outflow to skeletal muscles are not adequately understood. The present study mapped these pathways through the transneuronal transport of two recombinant strains of pseudorabies virus (PRV) injected into the gastrocnemius muscles in the left and right hindlimbs of rats: PRV-152 and PRV-BaBlu. To prevent PRV from being transmitted to the brain stem via motor circuitry, a spinal transection was performed just below the L2 level. Infected neurons were observed bilaterally in all of the areas of the brain that have previously been shown to contribute to regulating sympathetic outflow: the medullary raphe nuclei, rostral ventrolateral medulla (RVLM), rostral ventromedial medulla, A5 adrenergic cell group region, locus coeruleus, nucleus subcoeruleus, and the paraventricular nucleus of the hypothalamus. The RVLM, the brain stem region typically considered to play the largest role in regulating muscle blood flow, contained neurons infected following the shortest postinoculation survival times. Approximately half of the infected RVLM neurons were immunopositive for tyrosine hydroxylase, indicating that they were catecholaminergic. Many (47%) of the RVLM neurons were dually infected by the recombinants of PRV injected into the left and right hindlimb, suggesting that the central nervous system has a limited capacity to independently regulate blood flow to left and right hindlimb muscles.

Transneuronal tracing of neural pathways that regulate hindlimb muscle blood flow. Publishing Authors By Initials

TK Lee,JH Lois,JH Troupe,TD Wilson,BJ Yates,

For similar enzymes and coenzymes: enzymes: oxidoreductases: oxygenases: mixed function oxygenases: tyrosine 3-monooxygenase research abstracts see: enzymes and coenzymes: enzymes: oxidoreductases: oxygenases: mixed function oxygenases: tyrosine 3-monooxygenase research

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Transneuronal tracing of neural pathways that regulate hindlimb muscle blood flow. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: American journal of physiology. Regulatory, integr

VOLUME: 292

Page Numbers: R1532-41

Journal Abbreviation: Am. J. Physiol. Regul. Integr.

ISSN: 0363-6119

DAY: 7

MONTH: 12

YEAR: 2006

Transneuronal tracing of neural pathways that regulate hindlimb muscle blood flow. Information

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LANGUAGE: eng

NlmUniqueID: 100901230

Transneuronal tracing of neural pathways that regulate hindlimb muscle blood flow. Keywords Mesh Terms:

KEYWORDS: Tyrosine 3-Monooxygenase

MESH TERMS: metabolism

Chemical & Substance for Abstract: Transneuronal tracing of neural pathways that regulate hindlimb muscle blood flow. Information

Substance Name: Tyrosine 3-Monooxygenase

Registry Number: EC 1.14.16.2

Grant and Affiliation Information for Transneuronal tracing of neural pathways that regulate hindlimb muscle blood flow.

AFFILIATION: University of Pittsburgh, School of Medicine, Department of Otolaryngology, Eye and Ear Institute, Rm. 519, Pittsburgh, PA 15213, USA.

Country: United States

AGENCY: United States NIDCD

GRANT: R01-DC00693

ACRONYM: DC

MEDLINETA: Am J Physiol Regul Integr Comp

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