Transmission mode ion/ion electron-transfer dissociation in a linear ion trap.

Transmission mode ion/ion electron-transfer dissociation in a linear ion trap. Research Abstract Details 

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Transmission mode ion/ion electron-transfer dissociation in a linear ion trap. Abstract Text:

Xiaorong Liang,James W Hager,Scott A McLuckey,

Two related methods for effecting electron-transfer dissociation (ETD) are described that involve either the storage of analyte cations in a linear ion trap while reagent anions are transmitted through the cations or storage of the reagent anions with transmission of the analyte cations. In the former approach, the ETD products are captured and stored in the linear ion trap for subsequent mass analysis. In the latter approach, the ETD products pass through the linear ion trap and must be collected or directly mass-analyzed by an external device. In the present study, another linear ion trap is placed in series with the ion trap where the ion/ion reaction was employed. A pulsed dual ion source approach coupled with a hybrid triple quadrupole/linear ion trap instrument was used to illustrate these methods. The two approaches give similar results in terms of the identities and relative abundances of the ETD products. Under optimum conditions, the two approaches also give comparable extents of ion/ion reactions for the same reaction time. Also, conversions of precursor ions to product ions over the same reaction time are similar to those noted for experiments in which ions of both polarities are stored simultaneously. These approaches, therefore, provide expanded experimental options for the use of ETD. An advantage of transmission mode experiments that they hold over mutual storage mode experiments is that they do not require that any specialized measures be taken to enable the simultaneous storage of oppositely charged ions.

Transmission mode ion/ion electron-transfer dissociation in a linear ion trap. Publishing Authors By Initials

X Liang,JW Hager,SA McLuckey,

For similar investigative techniques: epidemiologic methods: statistics as topic: sensitivity and specificity research abstracts see: investigative techniques: epidemiologic methods: statistics as topic: sensitivity and specificity research

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Transmission mode ion/ion electron-transfer dissociation in a linear ion trap. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Analytical chemistry

VOLUME: 79

Page Numbers: 3363-70

Journal Abbreviation:

ISSN: 0003-2700

DAY: 28

MONTH: 03

YEAR: 2007

Transmission mode ion/ion electron-transfer dissociation in a linear ion trap. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 370536

Transmission mode ion/ion electron-transfer dissociation in a linear ion trap. Keywords Mesh Terms:

KEYWORDS: Sensitivity and Specificity

MESH TERMS: analysis

Chemical & Substance for Abstract: Transmission mode ion/ion electron-transfer dissociation in a linear ion trap. Information

Substance Name: Peptide Fragments

Registry Number: 0

Grant and Affiliation Information for Transmission mode ion/ion electron-transfer dissociation in a linear ion trap.

AFFILIATION: Department of Chemistry, Purdue University, West Lafayette, Indiana 47907-2084, USA.

Country: United States

AGENCY: United States NIGMS

GRANT: GM 45372

ACRONYM: GM

MEDLINETA: Anal Chem

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