OBJECTIVE: To investigate the relationship between two polymorphisms (Intronic VNTR and 5-HTTLPR) of the serotonin transporter gene and schizophrenia. METHODS: A set of 314 schizophrenic trio samples collected from Shanghai, Xi'an and Jilin regions of China independently was subjected to analysis of the polymorphisms by transmission/disequilibrium test(TDT). RESULTS: No significantly preferential transmission of any allele was detected from both polymorphisms investigated. CONCLUSION: The results suggest that the serotonin transporter gene is unlikely to have a major contribution to susceptibility to schizophrenia in Han Chinese population.
[Transmission disequilibrium test of polymorphisms of serotonin transporter gene and schizophrenia based on family trios] Publishing Authors By Initials
[Transmission disequilibrium test of polymorphisms of serotonin transporter gene and schizophrenia based on family trios] Journal Published:
PUBLICATION TYPE: Research Support, Non-U.S. Gov
Journal: Zhonghua yi xue yi chuan xue za zhi = Zhonghua yix
VOLUME: 20
Page Numbers: 342-4
Journal Abbreviation: Zhonghua Yi Xue Yi Chuan Xue Z
ISSN: 1003-9406
DAY: 6
MONTH: Aug
YEAR: 2003
[Transmission disequilibrium test of polymorphisms of serotonin transporter gene and schizophrenia based on family trios] Information
Number of References:
LANGUAGE: chi
NlmUniqueID: 9425197
[Transmission disequilibrium test of polymorphisms of serotonin transporter gene and schizophrenia based on family trios] Keywords Mesh Terms:
KEYWORDS:
MESH TERMS:
Chemical & Substance for Abstract: [Transmission disequilibrium test of polymorphisms of serotonin transporter gene and schizophrenia based on family trios] Information
Substance Name:
Registry Number:
Grant and Affiliation Information for [Transmission disequilibrium test of polymorphisms of serotonin transporter gene and schizophrenia based on family trios]
AFFILIATION: Bio-X Life Science Research Center, Shanghai Jiaotong University, Shanghai, 200030 PR China.
Country: China
AGENCY:
GRANT:
ACRONYM:
MEDLINETA: Zhonghua Yi Xue Yi Chuan Xue Z
REFSOURCE:
DATABASENAME:
ACCESSION NUMBER:
Number Hits: 0
Transmission disequilibrium test of polymorphisms of serotonin transporter gene and schizophrenia based on family trios Related Publications