Translocation of human ribosomal protein S3 to sites of DNA damage is dependant on ERK-mediated phosphorylation following genotoxic stress.

Translocation of human ribosomal protein S3 to sites of DNA damage is dependant on ERK-mediated phosphorylation following genotoxic stress. Research Abstract Details 

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Translocation of human ribosomal protein S3 to sites of DNA damage is dependant on ERK-mediated phosphorylation following genotoxic stress. Abstract Text:

Sridevi Yadavilli,Vijay Hegde,Walter A Deutsch,Sridevi Yadavilli,Vijay Hegde,Walter A Deutsch,

Besides its role in translation and ribosome maturation, human ribosomal protein S3 (hS3) is implicated in DNA damage recognition as reflected by its affinity for abasic sites and 7,8-dihydro-8-oxoguanine (8-oxoG) residues in DNA in vitro. Here, we demonstrate that hS3 is capable of carrying out both roles by its ex vivo translocation from the cytoplasm to the nucleus as a consequence of genotoxic stress. The translocation of hS3 is dependent on ERK1/2-mediated phosphorylation of a threonine residue (T42) of hS3. Two different ectopically expressed site-directed mutants of T42 failed to respond to conditions of genotoxic stress, thus providing a link between DNA damage and ERK1/2 dependent phosphorylation of hS3. Lastly, hS3 was traced in exposed cells to its co-localization with 8-oxoG foci, raising the possibility that hS3 is a member of a cellular DNA damage response pathway that results in its interaction with sites of DNA damage.

Translocation of human ribosomal protein S3 to sites of DNA damage is dependant on ERK-mediated phosphorylation following genotoxic stress. Publishing Authors By Initials

S Yadavilli,V Hegde,WA Deutsch,S Yadavilli,V Hegde,WA Deutsch,

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Translocation of human ribosomal protein S3 to sites of DNA damage is dependant on ERK-mediated phosphorylation following genotoxic stress. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: DNA repair

VOLUME: 6

Page Numbers: 1453-62

Journal Abbreviation: DNA Repair (Amst.)

ISSN: 1568-7864

DAY: 7

MONTH: 06

YEAR: 2007

Translocation of human ribosomal protein S3 to sites of DNA damage is dependant on ERK-mediated phosphorylation following genotoxic stress. Information

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LANGUAGE: eng

NlmUniqueID: 101139138

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Grant and Affiliation Information for Translocation of human ribosomal protein S3 to sites of DNA damage is dependant on ERK-mediated phosphorylation following genotoxic stress.

AFFILIATION: Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA 70808, USA.

Country: Netherlands

AGENCY: United States NCI

GRANT: CA 109798

ACRONYM: CA

MEDLINETA: DNA Repair (Amst)

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