Translocation mechanism of long sugar chains across the maltoporin membrane channel.

Translocation mechanism of long sugar chains across the maltoporin membrane channel. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Translocation mechanism of long sugar chains across the maltoporin membrane channel. Abstract Text:

Raimund Dutzler,Tilman Schirmer,Martin Karplus,Stefan Fischer,

Maltoporin allows permeation of long maltodextrin chains. It tightly binds the amphiphilic sugar, offering both hydrophobic interactions with a helical lane of aromatic residues and H bonds with ionic side chains. The minimum-energy path of maltohexaose translocation is obtained by the conjugate peak refinement method, which optimizes a continuous string of conformers without applying constraints. This reveals that the protein is passive while the sugar glides screw-like along the aromatic lane. Near instant switching of sugar hydroxyl H bond partners results in two small energy barriers (of approximately 4 kcal/mol each) during register shift by one glucosyl unit, in agreement with a kinetic analysis of experimental dissociation rates for varying sugar chain lengths. Thus, maltoporin functions like an efficient translocation "enzyme," and the slow rate of the register shift (approximately 1/ms) is due to high collisional friction.

Translocation mechanism of long sugar chains across the maltoporin membrane channel. Publishing Authors By Initials

R Dutzler,T Schirmer,M Karplus,S Fischer,

For similar natural sciences: physics: thermodynamics research abstracts see: natural sciences: physics: thermodynamics research

PUBMED ID PMID:

MEDLINE DATE:

Translocation mechanism of long sugar chains across the maltoporin membrane channel. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Structure (London, England : 1993)

VOLUME: 10

Page Numbers: 1273-84

Journal Abbreviation: Structure

ISSN: 0969-2126

DAY: 27

MONTH: Sep

YEAR: 2002

Translocation mechanism of long sugar chains across the maltoporin membrane channel. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 101087697

Translocation mechanism of long sugar chains across the maltoporin membrane channel. Keywords Mesh Terms:

KEYWORDS: Thermodynamics

MESH TERMS: metabolism

Chemical & Substance for Abstract: Translocation mechanism of long sugar chains across the maltoporin membrane channel. Information

Substance Name: maltohexaose

Registry Number: 34620-77-4

Grant and Affiliation Information for Translocation mechanism of long sugar chains across the maltoporin membrane channel.

AFFILIATION: Department of Structural Biology, Biozentrum, University of Basel, CH-4056 Basel, Switzerland.

Country: United States

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Structure

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Translocation mechanism of long sugar chains across the maltoporin membrane channel Related Publications

• A high-throughput screening platform for inhibitors of the riboflavin biosynthesis pathway.
• A prospective masked observational study of uterine contraction frequency in twins.
• A role for cyclooxygenase-2 in ultraviolet light-induced skin carcinogenesis.
• Blastocystis hominis and travelers.
• Carcinoma of the ampulla of Vater: comparative histologic/immunohistochemical classification and follow-up.
• Comparative analysis of calcineurin inhibition by complexes of immunosuppressive drugs with human FK506 binding proteins.
• Composition of the Volatile Oils from the Roots, Leaves and Fruits of Different Taxa of Apium graveolens.
• Cyanogenesis in Passiflora spp.
• Detection of Brugia parasite DNA in human blood by real-time PCR.
• Detection of scale-specific community dynamics using wavelets.
• Do age- and sex-related variations reliably reflect body size in non-human primate vocalizations? A review.
• Effect of Intralipid on clearance and organ uptake of bacteria in intra-abdominal sepsis in rats.
• Effect of oxygen concentration in the incubator's gas phase on the development of cultured preimplantation rabbit embryos.
• Expression of Nox1 in 3T3 cells increases cellular acid production but not proton conductance.
• Identification of genes that interact with Drosophila liquid facets.
• Maternal fish consumption, mercury levels, and risk of preterm delivery.
• Nitrogen sparing effects and mechanisms of branched-chain amino acids in the injured rat.
• Protein expression profiles in the epidermis of cyclooxygenase-2 transgenic mice by 2-dimensional gel electrophoresis and mass spectrometry.
• Regulation of seed size by hypomethylation of maternal and paternal genomes.
• Role of myokines in exercise and metabolism.
• Spinal cord ependymomas.
• The Essential Oil in Lamina and Petiole of Heracleum dissectum Leaves.
• The Helicobacter pylori CagF protein is a type IV secretion chaperone-like molecule that binds close to the C-terminal secretion signal of the CagA effector protein.
• The determination of (R)- and (S)-glutethimide and the corresponding 4-hydroxyglutethimide metabolises in human serum and urine using a Pirkle-type HPLC chiral stationary phase.
• The effect of vitamin E acetate on ultraviolet-induced mouse skin carcinogenesis.
• The use of branched chain amino acids (BCAA) in acute hepatic encephalopathy.
• Translocation mechanism of long sugar chains across the maltoporin membrane channel.
• Travel medicine: an American view of the Australian perspective.
• Use of buprenorphine in pregnancy: patient management and effects on the neonate.
• [Knowledge and practices by adolescents in preventing occupational injuries: a qualitative study]