Translational control of maternal Cyclin B mRNA by Nanos in the Drosophila germline.

Translational control of maternal Cyclin B mRNA by Nanos in the Drosophila germline. Research Abstract Details 

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Translational control of maternal Cyclin B mRNA by Nanos in the Drosophila germline. Abstract Text:

Lyudmila Y Kadyrova,Yasuaki Habara,Tammy H Lee,Robin P Wharton,

In the Drosophila embryo, Nanos and Pumilio collaborate to repress the translation of hunchback mRNA in the somatic cytoplasm. Both proteins are also required for repression of maternal Cyclin B mRNA in the germline; it has not been clear whether they act directly on Cyclin B mRNA, and if so, whether regulation in the presumptive somatic and germline cytoplasm proceeds by similar or fundamentally different mechanisms. In this report, we show that Pumilio and Nanos bind to an element in the 3' UTR to repress Cyclin B mRNA. Regulation of Cyclin B and hunchback differ in two significant respects. First, Pumilio is dispensable for repression of Cyclin B (but not hunchback) if Nanos is tethered via an exogenous RNA-binding domain. Nanos probably acts, at least in part, by recruiting the CCR4-Pop2-NOT deadenylase complex, interacting directly with the NOT4 subunit. Second, although Nanos is the sole spatially limiting factor for regulation of hunchback, regulation of Cyclin B requires another Oskar-dependent factor in addition to Nanos. Ectopic repression of Cyclin B in the presumptive somatic cytoplasm causes lethal nuclear division defects. We suggest that a requirement for two spatially restricted factors is a mechanism for ensuring that Cyclin B regulation is strictly limited to the germline.

Translational control of maternal Cyclin B mRNA by Nanos in the Drosophila germline. Publishing Authors By Initials

LY Kadyrova,Y Habara,TH Lee,RP Wharton,

For similar proteins: transcription factors research abstracts see: proteins: transcription factors research

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Translational control of maternal Cyclin B mRNA by Nanos in the Drosophila germline. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Development (Cambridge, England)

VOLUME: 134

Page Numbers: 1519-27

Journal Abbreviation: Development

ISSN: 0950-1991

DAY: 14

MONTH: 03

YEAR: 2007

Translational control of maternal Cyclin B mRNA by Nanos in the Drosophila germline. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8701744

Translational control of maternal Cyclin B mRNA by Nanos in the Drosophila germline. Keywords Mesh Terms:

KEYWORDS: Transcription Factors

MESH TERMS: metabolism

Chemical & Substance for Abstract: Translational control of maternal Cyclin B mRNA by Nanos in the Drosophila germline. Information

Substance Name: Ribonucleases

Registry Number: EC 3.1.-

Grant and Affiliation Information for Translational control of maternal Cyclin B mRNA by Nanos in the Drosophila germline.

AFFILIATION: Howard Hughes Medical Institute, Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710, USA.

Country: England

AGENCY: United States NIGMS

GRANT: GM62947

ACRONYM: GM

MEDLINETA: Development

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