Translation of both complementary strands might govern early evolution of the genetic code.

Translation of both complementary strands might govern early evolution of the genetic code. Research Abstract Details 

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Translation of both complementary strands might govern early evolution of the genetic code. Abstract Text:

The updated structural and phylogenetic analyses of tRNA pairs with complementary anticodons provide independent support for our earlier finding, namely that these tRNA pairs concertedly show complementary second bases in the acceptor stem. Two implications immediately follow: first, that a tRNA molecule gained its present, complete, cloverleaf shape via duplication(s) of a shorter precursor. Second, that common ancestry is shared by two major components of the genetic code within the tRNA molecule--the classic code per se embodied in anticodon triplets, and the operational code of aminoacylation embodied primarily in the first three base pairs of the acceptor stems. In this communication we show that it might have been a double, sense-antisense, in-frame translation of the very first protein-encoding genes that directed the code's earliest expansion, thus preserving this fundamental dual-complementary link between acceptors and anticodons. Furthermore, the dual complementarity appears to be consistent with two mirror-symmetrical modes by which class I and II aminoacyl-tRNA synthetases recognize the cognate tRNAs--from the minor and major groove side of the acceptor stem, respectively.

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Translation of both complementary strands might govern early evolution of the genetic code. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: In silico biology

VOLUME: 7

Page Numbers: 309-18

Journal Abbreviation: In Silico Biol. (Gedrukt)

ISSN: 1386-6338

DAY: 16

MONTH: 04

YEAR: 2007

Translation of both complementary strands might govern early evolution of the genetic code. Information

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LANGUAGE: eng

NlmUniqueID: 9815902

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Grant and Affiliation Information for Translation of both complementary strands might govern early evolution of the genetic code.

AFFILIATION: School of Public Health, University of Texas, Houston, TX 77030, USA. andrei.s.rodin@uth.tmc.edu

Country: Netherlands

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MEDLINETA: In Silico Biol

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