Transient expression of LIM-domain transcription factors is coincident with delayed maturation of photoreceptors in the chicken retina.

Transient expression of LIM-domain transcription factors is coincident with delayed maturation of photoreceptors in the chicken retina. Research Abstract Details 

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Transient expression of LIM-domain transcription factors is coincident with delayed maturation of photoreceptors in the chicken retina. Abstract Text:

Andy J Fischer,Shane Foster,Melissa A Scott,Patrick Sherwood,Andy J Fischer,Shane Foster,Melissa A Scott,Patrick Sherwood,Andy J Fischer,Shane Foster,Melissa A Scott,Patrick Sherwood,

In the retina of warm-blooded vertebrates, photoreceptors are specified many days before the onset of synaptogenesis and the expression of photopigments. The factors that regulate the maturation of photoreceptors in the developing retina remain unknown. We report here that photoreceptors transiently express LIM-domain transcription factors during the development of the chicken retina. We examined the differentiation of photoreceptors through the normal course of embryonic development and at the far periphery of the postnatal retina, where the differentiation of photoreceptors is slowed and persists across a spatial gradient. In the embryonic retina, we find visinin-positive photoreceptors that transiently express Islet2 and Lim3 starting at E8 and ending around E15, but persisting in far peripheral regions of the retina through the first 2 weeks of postnatal development. During early stages of photoreceptor maturation, there is coincident and transient expression of the LIM-domain factors with axonin1, a cell surface glycoprotein that is a member of the immunoglobulin superfamily. Coincident with the downregulation of Islet2 and Lim3, we find the upregulation of calbindin, red/green opsin, rhodopsin, and a synaptic marker in the outer plexiform layer (OPL; dystrophin). In the periphery of the postnatal retina, photoreceptors that express Islet2, Lim3, and axonin1 do not overlap with photoreceptors that express calbindin, red/green opsin, rhodopsin, and dystrophin. We propose that Islet2 and Lim3 may promote the expression of genes that are involved in the early stages of differentiation but may suppress the expression of genes that are required in the mature photoreceptors. J. Comp. Neurol. 506:584-603, 2008. (c) 2007 Wiley-Liss, Inc.

Transient expression of LIM-domain transcription factors is coincident with delayed maturation of photoreceptors in the chicken retina. Publishing Authors By Initials

AJ Fischer,S Foster,MA Scott,P Sherwood,AJ Fischer,S Foster,MA Scott,P Sherwood,AJ Fischer,S Foster,MA Scott,P Sherwood,

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Transient expression of LIM-domain transcription factors is coincident with delayed maturation of photoreceptors in the chicken retina. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: The Journal of comparative neurology

VOLUME: 506

Page Numbers: 584-603

Journal Abbreviation: J. Comp. Neurol.

ISSN: 0021-9967

DAY: 1

MONTH: Feb

YEAR: 2008

Transient expression of LIM-domain transcription factors is coincident with delayed maturation of photoreceptors in the chicken retina. Information

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LANGUAGE: eng

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Grant and Affiliation Information for Transient expression of LIM-domain transcription factors is coincident with delayed maturation of photoreceptors in the chicken retina.

AFFILIATION: Department of Neuroscience, The Ohio State University, Columbus, Ohio 43210.

Country: United States

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MEDLINETA: J Comp Neurol

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• Transient expression of LIM-domain transcription factors is coincident with delayed maturation of photoreceptors in the chicken retina.