Transgenic over-expression of the microRNA miR-17-92 cluster promotes proliferation and inhibits differentiation of lung epithelial progenitor cells.

Transgenic over-expression of the microRNA miR-17-92 cluster promotes proliferation and inhibits differentiation of lung epithelial progenitor cells. Research Abstract Details 

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Transgenic over-expression of the microRNA miR-17-92 cluster promotes proliferation and inhibits differentiation of lung epithelial progenitor cells. Abstract Text:

Yun Lu,J Michael Thomson,Ho Yuen Frank Wong,Scott M Hammond,Brigid L M Hogan,Yun Lu,J Michael Thomson,Ho Yuen Frank Wong,Scott M Hammond,Brigid L M Hogan,

The miR-17-92 locus encodes a cluster of 7 microRNAs transcribed as a single primary transcript. It can accelerate c-Myc induced B cell lymphoma development and is highly expressed in many tumors, including lung tumors. However, the role of miR-17-92 in development has not been well studied. From analysis of microRNAs during lung development, expression of the miR-17-92 cluster is high at early stages, but declines as development proceeds. We used the mouse surfactant protein C (Sftpc) promoter to over-express the cluster in embryonic lung epithelium. Transgenic lungs have a very abnormal lethal phenotype. They contain numerous proliferative epithelial cells that retain high levels of Sox9, a marker of distal progenitors. The differentiation of proximal epithelial cells was also inhibited. Furthermore, a significant increase in the number of neuroendocrine cell clusters was observed in the lungs of dead transgenic pups. We identify a tumor suppressor, Rbl2 which belongs to the Rb family, as a new target for miR-17-5p. Together, these studies suggest that mir-17-92 normally promotes the high proliferation and undifferentiated phenotype of lung epithelial progenitor cells.

Transgenic over-expression of the microRNA miR-17-92 cluster promotes proliferation and inhibits differentiation of lung epithelial progenitor cells. Publishing Authors By Initials

Y Lu,JM Thomson,HY Wong,SM Hammond,BL Hogan,Y Lu,JM Thomson,HY Wong,SM Hammond,BL Hogan,

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Transgenic over-expression of the microRNA miR-17-92 cluster promotes proliferation and inhibits differentiation of lung epithelial progenitor cells. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Developmental biology

VOLUME: 310

Page Numbers: 442-53

Journal Abbreviation: Dev. Biol.

ISSN: 0012-1606

DAY: 9

MONTH: 08

YEAR: 2007

Transgenic over-expression of the microRNA miR-17-92 cluster promotes proliferation and inhibits differentiation of lung epithelial progenitor cells. Information

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LANGUAGE: eng

NlmUniqueID: 372762

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Grant and Affiliation Information for Transgenic over-expression of the microRNA miR-17-92 cluster promotes proliferation and inhibits differentiation of lung epithelial progenitor cells.

AFFILIATION: Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA.

Country: United States

AGENCY: United States NHLBI

GRANT: R01 HL071303-15

ACRONYM: HL

MEDLINETA: Dev Biol

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