Transgenic mouse lines expressing Cre recombinase specifically in posterior notochord and notochord.

Transgenic mouse lines expressing Cre recombinase specifically in posterior notochord and notochord. Research Abstract Details 

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Transgenic mouse lines expressing Cre recombinase specifically in posterior notochord and notochord. Abstract Text:

Amit Kumar,Taihei Yamaguchi,Prashant Sharma,Michael R Kuehn,Amit Kumar,Taihei Yamaguchi,Prashant Sharma,Michael R Kuehn,Amit Kumar,Taihei Yamaguchi,Prashant Sharma,Michael R Kuehn,

During development, the organizer provides instructive signals to surrounding cells as well as contributing cells to axial structures. To dissect organizer function at different developmental stages, conditional approaches such as the Cre/loxP system for conditional mutagenesis are particularly useful. Here we describe two new Cre transgenic mouse lines, Foxa2 NFP-Cre and Nodal PNC-Cre, with activity in two organizer domains, the posterior notochord (PNC) and notochord. These lines were made using defined regulatory elements from the Foxa2 and Nodal genes that direct Cre expression in overlapping domains of the PNC and notochord. Our detailed analysis of the timing and location of Foxa2 NFP-Cre and Nodal PNC-Cre activity indicates that these lines are appropriate for conditional mutagenesis of genes expressed from early somite stages onward. genesis 45:729-736, 2007. Published 2007 Wiley-Liss, Inc.

Transgenic mouse lines expressing Cre recombinase specifically in posterior notochord and notochord. Publishing Authors By Initials

A Kumar,T Yamaguchi,P Sharma,MR Kuehn,A Kumar,T Yamaguchi,P Sharma,MR Kuehn,A Kumar,T Yamaguchi,P Sharma,MR Kuehn,

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Transgenic mouse lines expressing Cre recombinase specifically in posterior notochord and notochord. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Genesis (New York, N.Y. : 2000)

VOLUME: 45

Page Numbers: 729-36

Journal Abbreviation: Genesis

ISSN: 1526-954X

DAY: 13

MONTH: Dec

YEAR: 2007

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LANGUAGE: eng

NlmUniqueID: 100931242

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AFFILIATION: Laboratory of Protein Dynamics and Signaling, National Cancer Institute, NCI-Frederick, National Institutes of Health, Frederick, Maryland.

Country: United States

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MEDLINETA: Genesis

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