Transgenic mice carrying yeast artificial chromosomes.

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Transgenic mice carrying yeast artificial chromosomes. Abstract Text:

Kenneth R Peterson,Kenneth R Peterson,

The generation of transgenic mice with yeast artificial chromosomes (YACs) has proven to be a valuable system to: (1) study gene structure-function relationships; (2) produce mouse models of human disease; (3) complement mouse mutants; (4) generate mice bioreactors; and (5) screen YAC libraries in vivo. Continued refinement of current techniques and development of new protocols should encourage widespread adaptation of this strategy for these and other applications. Use of whole loci as transgenes is an important improvement in murine transgenesis because it results in a more realistic pattern and level of gene expression during ontogeny. Application of this technology to develop human artificial chromosomes (HACs) might provide the next generation of gene therapy vectors that will overcome most of the problems and barriers associated with current vector systems.

Transgenic mice carrying yeast artificial chromosomes. Publishing Authors By Initials

KR Peterson,KR Peterson,

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Transgenic mice carrying yeast artificial chromosomes. Journal Published:

PUBLICATION TYPE: Review

Journal: Expert reviews in molecular medicine

VOLUME: 5

Page Numbers: 1-25

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ISSN: 1462-3994

DAY: 7

MONTH: 04

YEAR: 2003

Transgenic mice carrying yeast artificial chromosomes. Information

Number of References: 182

LANGUAGE: eng

NlmUniqueID: 100939725

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Grant and Affiliation Information for Transgenic mice carrying yeast artificial chromosomes.

AFFILIATION: Department of Biochemistry and Molecular Biology, 3901 Rainbow Blvd, University of Kansas Medical Center, Kansas City, KS 66160, USA. kpeterson@kumc.edu

Country: England

AGENCY: United States NHLBI

GRANT: HL67336

ACRONYM: HL

MEDLINETA: Expert Rev Mol Med

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