Transgenic farm animals - A critical analysis.

Transgenic farm animals - A critical analysis. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Transgenic farm animals - A critical analysis. Abstract Text:

R J Wall,G E Seidel,

The notion of directly introducing new genes or otherwise manipulating the genotype of an animal is conceptually straightforward and appealing from the standpoints of both speed and precision with which phenotypic changes can be made. Thus, it is little wonder that the imagination of many animal scientists has been captivated by the success others have achieved in introducing foreign genes into mice. Transgenic mice not only exhibit unique phenotypes, but they also pass those traits on to their progeny. However, before transgenic farm animals become a common component of the livestock industry, a number of formidable obstacles must be overcome. In this review we attempt to identify the critical issues that should be considered by both those currently working in the field and those scientists considering the feasibility of initiating a transgenic livestock project. The inefficiency of producing transgenic animals has been well documented. This does not constrain investigators using laboratory animal models, but it has a major impact on applying transgenic technology to farm animals. The molecular mechanisms of transgene integration have not been elucidated, and as a consequence it is difficult to design strategies to improve the efficiency of the process. In addition to the problems associated with integration of new genes, there are inefficiencies associated with collecting and culturing fertilized eggs as well as embryo transfer in farm animals. Transgenic farm animal studies are major logistical undertakings. Even in the face of these practical hindrances, some may be pressured by administrators to embrace this new technology. As powerful as the transgenic animal model system is, currently there are limits to the kinds of agricultural questions that can be addressed. Some uses are so appealing, however, that several commercial organizations have explored this technology. Within the next decade or two, it is likely that many of the technical hurdles will be overcome. Combining new techniques with a better understanding of the genetic control of physiological systems will make it possible to improve the characteristics of farm animals in highly imaginative ways.

Transgenic farm animals - A critical analysis. Publishing Authors By Initials

RJ Wall,GE Seidel,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Transgenic farm animals - A critical analysis. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Theriogenology

VOLUME: 38

Page Numbers: 337-57

Journal Abbreviation: Theriogenology

ISSN: 0093-691X

DAY: 26

MONTH: Aug

YEAR: 1992

Transgenic farm animals - A critical analysis. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 421510

Transgenic farm animals - A critical analysis. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Transgenic farm animals - A critical analysis. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Transgenic farm animals - A critical analysis.

AFFILIATION: U.S. Department of Agriculture, Agricultural Research Service, Beltsville Agricultural Research Center, Gene Evaluation and Mapping Lab., Beltsville, Maryland 20705, USA.

Country: United States

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Theriogenology

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Transgenic farm animals - A critical analysis Related Publications

• A molecular oyster: a neutral anion receptor containing two cyclopeptide subunits with a remarkable sulfate affinity in aqueous solution.
• A new procedure for the cryopreservation of equine embryos.
• Comparison of equine pituitary extract and follicle stimulating hormone for superovulating mares.
• Cryopreservation of the germplasm of animals used in biological and medical research: importance, impact, status, and future directions.
• Effects of GnRH on superovulated cattle.
• Effects of bovine follicular fluid on maturation of bovine oocytes.
• Effects of either glucose or fructose and metabolic regulators on bovine embryo development and lipid accumulation in vitro.
• Effects of fetal calf serum, phenazine ethosulfate and either glucose or fructose during in vitro culture of bovine embryos on embryonic development after cryopreservation.
• Elimination of heterodyne interferometer nonlinearity by carrier phase modulation.
• Experimental design, power and sample size for animal reproduction experiments.
• Interaction between two polyelectrolyte brushes.
• Method for producing transgenic bovine embryos from in vitro matured and fertilized oocytes.
• Ni(II)-Bis[(R,R)-N,N'-dibenzylcyclohexane-1,2-diamine]Br2 catalyzed enantioselective Michael additions of 1,3-dicarbonyl compounds to conjugated nitroalkenes.
• Non-surgical transfer of bovine embryos.
• Obestatin and ghrelin in obese and in pregnant women.
• Pediatric interventional radiology workforce survey summary.
• Pregnancy rates in previously falled bovine embryo transfer recipients.
• Pregnancy rates with bisected bovine embryos.
• Scope and mechanism of enantioselective Michael additions of 1,3-dicarbonyl compounds to nitroalkenes catalyzed by nickel(II)-diamine complexes.
• Sex ratio and mortality of calves from embryo transfer.
• Substantia nigra hyperechogenicity correlates with clinical status and number of Parkin mutated alleles.
• Testis development, beef consumption and study methods.
• Topological visualization of brain diffusion MRI data.
• Transgenic farm animals - A critical analysis.
• Transport of frozen cattle embryos from U.S.A. to Mexico.
• Use of sucrose during removal of cryoprotectants after thawing eight-cell mouse embryos.
• Vitrification of bovine oocytes after treatment with cholesterol-loaded methyl-beta-cyclodextrin.
• [In Process Citation]
• [On the practical use of Salmonella typhimurium lysotypes in veterinary medicine.]
• [Studies on the formation of N1-oxides of cytosine and cytosine derivatives.]